A robust H8 control approach for blood glucose regulation in type-1 diabetes

L. Cassany, D. Gucik-Derigny, J. Cieslak, D. Henry, R. Franco, A. Ferreira De Loza, H. Ríos, L. Olçomendy, A. Pirog, Y. Bornat, S. Renaud, B. Catargi

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


The paper addresses the design of a H8 closed-loop dedicated to Blood Glucose (BG) regulation for patients affected by Type-1 Diabetes Mellitus (T1DM). The closed-loop setup is standard, i.e. the H8 feedback controller uses the information provided by a subcutaneous sensor to drive an insulin pump but as opposed to current existing solutions, it is proposed to assess the capabilities of a H8 controller to be designed in a patient-independent way. For that purpose, the design is performed on a family of linear models in order to tackle the variability of a cohort of T1DM patients. Worst-case performance and robust margins are next computed with the help of the H8/µ-analysis theory. The solution is finally assessed on the adult cohort of the high-fidelity UVA/Padova benchmark (v3.2), accepted by the US Food and Drug Administration (FDA) as a substitute for pre-clinical testing of control strategies.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
Issue number15
StatePublished - 2021
Externally publishedYes
Event11th IFAC Symposium on Biological and Medical Systems BMS 2021 - Ghent, Belgium
Duration: 19 Sep 202122 Sep 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors.


  • Blood Glucose Regulation
  • H8 control
  • Type 1 Diabetes Mellitus


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