Actividad antitumoral de biopolímeros aislados de Vibrio sp. en cáncer de mama inducido en ratas

Translated title of the contribution: Antitumor activity of Vibrio sp. isolated biopolymers in induced breast cancer in rats

Daisy Flores-Cortez, Eduardo Villalobos-Pacheco, Danilo Chávez-Rojas, Davila Juan Manuel Rodriguez Tafur, Manuel Palomino-Yamamoto

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the antitumor activity of the raw extract from biopolymers isolated from the Vibrio sp. marine bacteria in breast cancer induced by N-Methyl-N-nitrosourea (MNU) in rats. Materials and methods: The Vibrio sp. marine bacteria was cultured for seven days, then the raw supernatant was filtered, precipitated and concentrated. MNU was administered in a single dose of 50 mg/kg to 39 Holtzman rats and were daily treated for 9 weeks orally: G1 (n = 13): 0.1 mL/100 g of saline solution; G2 (n = 13): 20 mg/kg of raw extract from Vibrio sp. biopolymers; G3 (n = 13): 100 mg/kg of tamoxifen; G4 (n = 11) received no MNU and only 0.1 mL/100 g of saline solution. Body weight and the appearance of breast tumors identified by palpation were assessed weekly, as well as histopathological examination at the end of treatment. Results: Seventy-seven percent of the rats in the G1 group developed tumors from week 7 onwards in an average of 2.2 tumors per animal; in contrast to the group treated with the raw biopolymer extract and tamoxifen; where only one rat (8%) in each group developed tumors after week nine of induction (p = 0.001). The histopathological results support that all the removed tumors correspond to breast ductal adenocarcinoma with different patterns: solid, papillary and cystic. Likewise, necrotic foci were evidenced in 30% of the tumors of the G1 group. Conclusion: The raw extract of biopolymers isolated from Vibrio sp. present antitumor effect in breast cancer induced in rats.

Translated title of the contributionAntitumor activity of Vibrio sp. isolated biopolymers in induced breast cancer in rats
Original languageSpanish
Pages (from-to)246-252
Number of pages7
JournalRevista Peruana de Medicina Experimental y Salud Publica
Issue number2
StatePublished - 2020

Bibliographical note

Funding Information:
Agradecimientos: A la Dra. Rita Orozco Moreira del Laboratorio de Microbiología del Instituto del Mar del Perú y al Dr. Hernán Velarde del Instituto de Patología de la Facultad de Medicina de la UNMSM, El proyecto fue financiado por el Vicerrectorado de Investigación de la UNMSM (Resolución Rectoral N.° 01414-R-12. Código del proyecto: 120114011).

Publisher Copyright:
© 2020, Instituto Nacional de Salud. All rights reserved.


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