An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
Rojas, R., Caviedes, L., Aponte, J. C., Vaisberg, A. J., Lewis, W. H., Lamas, G., Sarasara, C., Gilman, R. H., & Hammond, G. B. (2006). Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera. Journal of Natural Products, 69(5), 845-846. https://doi.org/10.1021/np050554l