Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Rosario Rojas, Luz Caviedes, José C. Aponte, Abraham J. Vaisberg, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. Hammond

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Abstract

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
Original languageAmerican English
Pages (from-to)845-846
Number of pages2
JournalJournal of Natural Products
Volume69
Issue number5
DOIs
StatePublished - 1 May 2006

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    Rojas, R., Caviedes, L., Aponte, J. C., Vaisberg, A. J., Lewis, W. H., Lamas, G., Sarasara, C., Gilman, R. H., & Hammond, G. B. (2006). Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera. Journal of Natural Products, 69(5), 845-846. https://doi.org/10.1021/np050554l