Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Rosario Rojas, Luz Caviedes, José C. Aponte, Abraham J. Vaisberg, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. Hammond

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
Original languageAmerican English
Pages (from-to)845-846
Number of pages2
JournalJournal of Natural Products
Volume69
Issue number5
DOIs
StatePublished - 1 May 2006

Fingerprint

Dive into the research topics of 'Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera'. Together they form a unique fingerprint.

Cite this