Albendazole therapy for neurocysticercosis: A prospective double-blind trial comparing 7 versus 14 days of treatment

H. H. Garcia, R. H. Gilman, J. Horton, M. Martinez, G. Herrera, J. Altamirano, J. M. Cuba, N. Rios-Saavedra, M. Verastegui, J. Boero, A. E. Gonzalez

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Abstract

Objective: To compare the effectiveness of two regimens of albendazole therapy for neurocysticercosis. Design: Randomized, double-blind clinical trial. Settings: Patients admitted to neurologic wards in Lima, Peru. Patients: Adult patients with active neurocysticercosis demonstrated by CT and Western blot (immunoblot). Intervention: One week (n = 25) versus 2 weeks (n = 25) of albendazole therapy. Measurements: Decrease in the number of cysts on CT. Results: Effectiveness of albendazole was 78%, with no difference between the groups when compared 3 months after therapy. Complete cure was obtained in only 38% of patients. Patients with more than 20 cysts had poorer responses to therapy. The clinical course and EEG evolution improved in most patients. Side effects were present in 38% of patients, mainly mild, transient gastrointestinal symptoms. Therapy was also associated with exacerbation of neurologic symptoms. Two patients died in the first year after therapy, both because of aggregated infections of ventricle-peritoneal shunts. One-year follow-up CT showed lesions in three of 10 patients presumed to be cured 3 months after therapy. Conclusions: Extension of albendazole therapy for more than 7 days adds no benefits for the patients.
Original languageAmerican English
Pages (from-to)1421-1427
Number of pages7
JournalNeurology
DOIs
StatePublished - 1 Jan 1997
Externally publishedYes

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    Garcia, H. H., Gilman, R. H., Horton, J., Martinez, M., Herrera, G., Altamirano, J., Cuba, J. M., Rios-Saavedra, N., Verastegui, M., Boero, J., & Gonzalez, A. E. (1997). Albendazole therapy for neurocysticercosis: A prospective double-blind trial comparing 7 versus 14 days of treatment. Neurology, 1421-1427. https://doi.org/10.1212/WNL.48.5.1421