Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study

Teodoro Julio Oscanoa Espinoza, Edwin C. Cieza, Frank A. Lizaraso-Soto, María L. Guevara, Ricardo M. Fujita, Román Romero-Ortuño

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Some studies have suggested that the insertion(I)/deletion(D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene may be associated with human longevity, especially in centenarians. However, this association is still controversial. Besides, there have been no studies in Peruvians. Aim: To describe the age distribution of the ACE polymorphism in a convenience sample of Peruvian older people. Subjects and methods: This was a cross-sectional study in 104 Geriatric Day Hospital patients in Lima, Perú. The ACE polymorphism was determined in all patients. For the purpose of association with age, the sample was divided into four categories: young (< 65), youngest-old (65–74), middle-old (75–84) and oldest-old (85 or more). Results: The distribution of genotype frequencies was consistent with a population in Hardy-Weinberg equilibrium (p = 0.62). The number (%) of D/D, I/D and I/I genotypes in the young was 2 (14.3%), 3 (21.4%) and 9 (64.3%), respectively; in youngest-old: 4 (11.4%), 15 (42.9%) and 16 (45.7%); in middle-old: 6 (12.2%), 20 (40.8%) and 23 (46.9%); and in oldest-old: 0 (0.0%), 4 (66.7%) and 2 (33.3%). A chi-square analysis showed no significant differences in genotype distribution between age groups (p = 0.647). Conclusion: No significant age differences were found in the distribution of the ACE polymorphism in this sample. Further studies with greater statistical power are recommended.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalAnnals of Human Biology
Volume47
Issue number3
DOIs
StatePublished - 2 Apr 2020
Externally publishedYes

Bibliographical note

Funding Information:
ESSALUD??Kaelin Award, Instituto de Evaluaci?n e Investigaci?n de Tecnolog?as de la Salud-IETSI? [Code: 04-IETSI-ESSALUD-2016], Lima, Per?. Rom?n Romero-Ortuno is funded by Science Foundation Ireland under the President of Ireland Future Research Leaders programme [18/FRL/6188].

Publisher Copyright:
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • ACE gene
  • Longevity
  • Perú
  • ageing

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