Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

C. T. Kyngdon; C. G. Gauci; A. E. Gonzalez; A. Flisser; A. Zoli; A. J. Read; J. Martínez-Ocaña; R. A. Strugnell; M. W. Lightowlers

doi:10.1111/j.1365-3024.2006.00820.x

Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

C. T. Kyngdon, C. G. Gauci, A. E. Gonzalez, A. Flisser, A. Zoli, A. J. Read, J. Martínez-Ocaña, R. A. Strugnell, M. W. Lightowlers

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species. © 2006 Blackwell Publishing Ltd.

Original language	American English
Pages (from-to)	191-199
Number of pages	9
Journal	Parasite Immunology
DOIs	https://doi.org/10.1111/j.1365-3024.2006.00820.x
State	Published - 1 May 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1365-3024.2006.00820.x

Cite this

@article{f6cea97aff6e419b86bfd3aba7298404,

title = "Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A",

abstract = "Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species. {\textcopyright} 2006 Blackwell Publishing Ltd.",

author = "Kyngdon, {C. T.} and Gauci, {C. G.} and Gonzalez, {A. E.} and A. Flisser and A. Zoli and Read, {A. J.} and J. Mart{\'i}nez-Oca{\~n}a and Strugnell, {R. A.} and Lightowlers, {M. W.}",

year = "2006",

month = may,

day = "1",

doi = "10.1111/j.1365-3024.2006.00820.x",

language = "American English",

pages = "191--199",

journal = "Parasite Immunology",

issn = "0141-9838",

publisher = "Wiley-Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

AU - Kyngdon, C. T.

AU - Gauci, C. G.

AU - Gonzalez, A. E.

AU - Flisser, A.

AU - Zoli, A.

AU - Read, A. J.

AU - Martínez-Ocaña, J.

AU - Strugnell, R. A.

AU - Lightowlers, M. W.

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species. © 2006 Blackwell Publishing Ltd.

AB - Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species. © 2006 Blackwell Publishing Ltd.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33645880437&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33645880437&origin=inward

U2 - 10.1111/j.1365-3024.2006.00820.x

DO - 10.1111/j.1365-3024.2006.00820.x

M3 - Article

SN - 0141-9838

SP - 191

EP - 199

JO - Parasite Immunology

JF - Parasite Immunology

ER -

Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this