Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

C. T. Kyngdon, C. G. Gauci, A. E. Gonzalez, A. Flisser, A. Zoli, A. J. Read, J. Martínez-Ocaña, R. A. Strugnell, M. W. Lightowlers

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22 Scopus citations

Abstract

Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalParasite Immunology
Volume28
Issue number5
DOIs
StatePublished - May 2006

Keywords

  • Epitopes
  • Fibronectin
  • TSOL18
  • TSOL45-1A
  • Taenia solium

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