TY - JOUR
T1 - Applications of adductomics in chemically induced adverse outcomes and major emphasis on DNA adductomics
T2 - A pathbreaking tool in biomedical research
AU - Behl, Tapan
AU - Rachamalla, Mahesh
AU - Najda, Agnieszka
AU - Sehgal, Aayush
AU - Singh, Sukhbir
AU - Sharma, Neelam
AU - Bhatia, Saurabh
AU - Al‐harrasi, Ahmed
AU - Chigurupati, Sridevi
AU - Vargas‐de‐la‐cruz, Celia
AU - Hobani, Yahya Hasan
AU - Mohan, Syam
AU - Goyal, Amit
AU - Katyal, Taruna
AU - Solarska, Ewa
AU - Bungau, Simona
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdiscipli-nary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society’s pressing challenges are pro-vided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents’ toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedi-cated database to identify adducts is further exacerbating the problem of adduct diagnosis. In ad-dition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.
AB - Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdiscipli-nary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society’s pressing challenges are pro-vided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents’ toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedi-cated database to identify adducts is further exacerbating the problem of adduct diagnosis. In ad-dition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.
KW - Adductomics
KW - Cancer detection tool
KW - DNA adduct
KW - Protein adduct
UR - http://www.scopus.com/inward/record.url?scp=85115193674&partnerID=8YFLogxK
U2 - 10.3390/ijms221810141
DO - 10.3390/ijms221810141
M3 - Artículo de revisión
C2 - 34576304
AN - SCOPUS:85115193674
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 18
M1 - 10141
ER -