Applications of adductomics in chemically induced adverse outcomes and major emphasis on DNA adductomics: A pathbreaking tool in biomedical research

Tapan Behl, Mahesh Rachamalla, Agnieszka Najda, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al‐harrasi, Sridevi Chigurupati, Celia Vargas‐de‐la‐cruz, Yahya Hasan Hobani, Syam Mohan, Amit Goyal, Taruna Katyal, Ewa Solarska, Simona Bungau

Research output: Contribution to journalReview articlepeer-review

Abstract

Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdiscipli-nary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society’s pressing challenges are pro-vided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents’ toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedi-cated database to identify adducts is further exacerbating the problem of adduct diagnosis. In ad-dition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.

Original languageEnglish
Article number10141
JournalInternational Journal of Molecular Sciences
Volume22
Issue number18
DOIs
StatePublished - Sep 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Adductomics
  • Cancer detection tool
  • DNA adduct
  • Protein adduct

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