Appraisal of the pharmacokinetic profile, histopathology, and stability studies of a fast dissolving oral film based on natural polysaccharide

Fatima Akbar Sheikh, Muhammad Naeem Aamir, Muhammad Tahir Haseeb, Muhammad Ajmal Shah, Muhammad Farid-Ul-Haq, Mohammed Alqarni, Celia Vargas-De-La-Cruz, Renald Blundell

Research output: Contribution to journalArticlepeer-review


The present research is designed to evaluate the pharmacokinetic profile, histological evaluation, and stability studies of an orodispersible film (ODF) of tizanidine (TZ) and meloxicam (MX) prepared from a natural polysaccharide, i.e., xanthan gum. In vivo release study of TZ and MX was performed in rabbits and results indicated the better pharmacokinetics parameters and improved the oral bioavailability when compared to the oral aqueous suspension and solution of TZ and MX, respectively. The intermediate stability studies were performed at 30±2°C and 65±5% RH, whereas, the accelerated stability studies were carried out at 40±2°C and 75±5% RH, respectively for the duration of six months and results indicated that the ODF was stable for six months without any substantial difference in essential physico-chemical parameters, mechanical attributes, and morphological constraints. The toxicity profile of ODF was determined through histopathology of vital organs after administering the ODF to the rabbits. Histopathology revealed that the tissues of all vital organs are normal and did not exhibit any abnormalities, lesions, or hemorrhage. Therefore, the ODF prepared from xanthan gum exhibited a non-toxic and stable formulation with a better pharmacokinetics profile of MX and TZ.

Original languageEnglish
Pages (from-to)937-944
Number of pages8
JournalPakistan Journal of Pharmaceutical Sciences
Issue number3
StatePublished - May 2022
Externally publishedYes

Bibliographical note

Funding Information:
The authors would like to extend their sincere appreciation to Taif University Researchers Supporting Project number (TURSP-2020/309), Taif University, Taif, Saudi Arabia and Higher Education Commission (HEC) of Pakistan for providing the scholarship and financial support to carry out this research under the “Indigenous 5000PhDFellowshipPhase-II,Batch-V”program.

Publisher Copyright:
© 2022 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.


  • fast dissolving film
  • orodispersible
  • polymeric film
  • Polysaccharides
  • solvent casting method


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