Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos

Ivonne Fanny Reyes-Mandujano; José E. Olivera-García; Manuel Taboada-Vega; Patricia Galvan-Sanchez; Amilcar Azcarza-Acuña; Aldo M. Yactayo-Flores; Luis A. Zuñiga-Ccoicca; Evelyn V. Leiva-Pachas; Efraín Paccori-García

doi:10.17843/rpmesp.2018.351.3595

Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos

Translated title of the contribution: Connection between genetic polymorphism of interleukin-1beta with chronic periodontitis in Peruvian adults

Ivonne Fanny Reyes-Mandujano, José E. Olivera-García, Manuel Taboada-Vega, Patricia Galvan-Sanchez, Amilcar Azcarza-Acuña, Aldo M. Yactayo-Flores, Luis A. Zuñiga-Ccoicca, Evelyn V. Leiva-Pachas, Efraín Paccori-García

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression. Results. The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21). Conclusions. The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.

Translated title of the contribution	Connection between genetic polymorphism of interleukin-1beta with chronic periodontitis in Peruvian adults
Original language	Spanish
Pages (from-to)	9-14
Number of pages	6
Journal	Revista Peruana de Medicina Experimental y Salud Publica
Volume	35
Issue number	1
DOIs	https://doi.org/10.17843/rpmesp.2018.351.3595
State	Published - 1 Jan 2018

Bibliographical note

Funding Information:
El desarrollo de esta investigación contó con el apoyo económico del Fondo de Innovación de Ciencia y Tecnología FINCyT, Resolución Directoral N° 30-2008-PCM/ FINCyT, contrato N°001-FINCyT-PIBAP 2008 y se realizó en el Laboratorio II-5 de Genética Molecular del Centro de Investigación de Bioquímica y Nutrición de la Facultad de Medicina de la Universidad Nacional Mayor De San Marcos.

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© 2018, Instituto Nacional de Salud. All rights reserved.

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Reyes-Mandujano, I. F., Olivera-García, J. E., Taboada-Vega, M., Galvan-Sanchez, P., Azcarza-Acuña, A., Yactayo-Flores, A. M., Zuñiga-Ccoicca, L. A., Leiva-Pachas, E. V., & Paccori-García, E. (2018). Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos. Revista Peruana de Medicina Experimental y Salud Publica, 35(1), 9-14. https://doi.org/10.17843/rpmesp.2018.351.3595

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title = "Asociaci{\'o}n del polimorfismo gen{\'e}tico de la interleucina-1beta con periodontitis cr{\'o}nica en adultos peruanos",

abstract = "Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression. Results. The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21). Conclusions. The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.",

keywords = "Chronic periodontitis, Cytokines, Genetic polymorphism, Polymerase chain reaction",

author = "Reyes-Mandujano, {Ivonne Fanny} and Olivera-Garc{\'i}a, {Jos{\'e} E.} and Manuel Taboada-Vega and Patricia Galvan-Sanchez and Amilcar Azcarza-Acu{\~n}a and Yactayo-Flores, {Aldo M.} and Zu{\~n}iga-Ccoicca, {Luis A.} and Leiva-Pachas, {Evelyn V.} and Efra{\'i}n Paccori-Garc{\'i}a",

year = "2018",

month = jan,

day = "1",

doi = "10.17843/rpmesp.2018.351.3595",

language = "Espa{\~n}ol",

volume = "35",

pages = "9--14",

journal = "Revista Peruana de Medicina de Experimental y Salud Publica",

issn = "1726-4634",

publisher = "Instituto Nacional de Salud",

number = "1",

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Reyes-Mandujano, IF, Olivera-García, JE, Taboada-Vega, M, Galvan-Sanchez, P, Azcarza-Acuña, A, Yactayo-Flores, AM, Zuñiga-Ccoicca, LA, Leiva-Pachas, EV & Paccori-García, E 2018, 'Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos', Revista Peruana de Medicina Experimental y Salud Publica, vol. 35, no. 1, pp. 9-14. https://doi.org/10.17843/rpmesp.2018.351.3595

TY - JOUR

T1 - Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos

AU - Reyes-Mandujano, Ivonne Fanny

AU - Olivera-García, José E.

AU - Taboada-Vega, Manuel

AU - Galvan-Sanchez, Patricia

AU - Azcarza-Acuña, Amilcar

AU - Yactayo-Flores, Aldo M.

AU - Zuñiga-Ccoicca, Luis A.

AU - Leiva-Pachas, Evelyn V.

AU - Paccori-García, Efraín

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression. Results. The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21). Conclusions. The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.

AB - Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression. Results. The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21). Conclusions. The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.

KW - Chronic periodontitis

KW - Cytokines

KW - Genetic polymorphism

KW - Polymerase chain reaction

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U2 - 10.17843/rpmesp.2018.351.3595

DO - 10.17843/rpmesp.2018.351.3595

M3 - Artículo

C2 - 29924285

AN - SCOPUS:85047783017

SN - 1726-4634

VL - 35

SP - 9

EP - 14

JO - Revista Peruana de Medicina de Experimental y Salud Publica

JF - Revista Peruana de Medicina de Experimental y Salud Publica

IS - 1

ER -

Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos

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