TY - JOUR
T1 - Association between developmental defects of enamel and early childhood caries in children under 6 years old
T2 - A systematic review and meta-analysis
AU - Castañeda-Sarmiento, Sara
AU - Uchima Koecklin, Karin Harumi
AU - Barahona Hernandez, Mayra Belen
AU - Santos, Gary Pereda
AU - Bruno Luyo, Julio César
AU - Sánchez Sotomayor, Julio César
AU - Ruiz-Yasuda, Catherine
AU - Apaza, Zenaida Rojas
AU - Adasme, David Paredes
AU - Torres Ricse, Dayhanne Alexsandra
AU - Mendoza Ballena, Marycielo Evelin
AU - Salcedo, Abad
AU - Ramirez-Sotelo, Laura Ricardina
AU - Blanco-Victorio, Daniel José
AU - Arieta-Miranda, Jessica
AU - Torres-Ramos, Gilmer
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/9
Y1 - 2022/9
N2 - Early childhood caries (ECC) are an oral health problem worldwide in children under 6 years of age. This disease of rapid development has a multifactorial etiology, and one of the possible risk factors is developmental defects of enamel (DDE), such as hypoplasia and opacities. The aim of this systematic review was to evaluate the association between DDE and ECC in children under 6 years of age. An electronic search was conducted until March 2022 using Medline (PubMed), Scopus, Science-Direct, LILACS, Web of Science, Cochrane Library, EBSCO-Host, EMBASE, and Google Scholar and complemented with a manual search, with no restrictions on language or date of publication. Longitudinal studies of children under 6 years of age with primary dentition were included. A total of 1158 studies were found, of which 651 records were reviewed by title and abstract, and 24 articles were selected for full-text evaluation. Finally, nine studies that met the selection criteria were included in the qualitative synthesis. Study quality and certainty were assessed using the Newcastle-Ottawa scale and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool. Three cohort studies of good quality were included in the meta-analysis. A risk associated with DDE (RR = 1.94; 95% CI: 1.52–2.49) and a risk associated with enamel hypoplasia (RR = 5.45; 95% CI: 1.84–16.14) were found. The results for diffuse opacity (RR = 1.21; 95% CI: 0.18–8.15) and demarcated opacity (RR = 1.26; 95% CI: 0.43–3.65) were not significant. GRADE analysis presented low and very low certainty of evidence. It was concluded that there is an association between DDE and ECC. However, the results should be interpreted with caution because of the limitations of the study. The protocol for this study has been registered in PROSPERO under identification number CRD42021238919.
AB - Early childhood caries (ECC) are an oral health problem worldwide in children under 6 years of age. This disease of rapid development has a multifactorial etiology, and one of the possible risk factors is developmental defects of enamel (DDE), such as hypoplasia and opacities. The aim of this systematic review was to evaluate the association between DDE and ECC in children under 6 years of age. An electronic search was conducted until March 2022 using Medline (PubMed), Scopus, Science-Direct, LILACS, Web of Science, Cochrane Library, EBSCO-Host, EMBASE, and Google Scholar and complemented with a manual search, with no restrictions on language or date of publication. Longitudinal studies of children under 6 years of age with primary dentition were included. A total of 1158 studies were found, of which 651 records were reviewed by title and abstract, and 24 articles were selected for full-text evaluation. Finally, nine studies that met the selection criteria were included in the qualitative synthesis. Study quality and certainty were assessed using the Newcastle-Ottawa scale and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool. Three cohort studies of good quality were included in the meta-analysis. A risk associated with DDE (RR = 1.94; 95% CI: 1.52–2.49) and a risk associated with enamel hypoplasia (RR = 5.45; 95% CI: 1.84–16.14) were found. The results for diffuse opacity (RR = 1.21; 95% CI: 0.18–8.15) and demarcated opacity (RR = 1.26; 95% CI: 0.43–3.65) were not significant. GRADE analysis presented low and very low certainty of evidence. It was concluded that there is an association between DDE and ECC. However, the results should be interpreted with caution because of the limitations of the study. The protocol for this study has been registered in PROSPERO under identification number CRD42021238919.
KW - Dental caries
KW - Dental enamel hypoplasia
KW - Enamel defects
KW - Pediatric dentistry
KW - Preschool child
KW - Primary teeth
UR - http://www.scopus.com/inward/record.url?scp=85137080818&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2022.e10479
DO - 10.1016/j.heliyon.2022.e10479
M3 - Artículo
AN - SCOPUS:85137080818
SN - 2405-8440
VL - 8
JO - Heliyon
JF - Heliyon
IS - 9
M1 - e10479
ER -