Bats are a major natural reservoir for hepaciviruses and pegiviruses

Phenix Lan Quan, Cadhla Firth, Juliette M. Conte, Simon H. Williams, Carlos M. Zambrana-Torrelio, Simon J. Anthony, James A. Ellison, Amy T. Gilbert, Ivan V. Kuzmin, Michael Niezgoda, Modupe O.V. Osinubi, Sergio Recuenco, Wanda Markotter, Robert F. Breiman, Lems Kalemba, Jean Malekani, Kim A. Lindblade, Melinda K. Rostal, Rafael Ojeda-Flores, Gerardo SuzanLora B. Davis, Dianna M. Blau, Albert B. Ogunkoya, Danilo A.Alvarez Castillo, David Moran, Sali Ngam, Dudu Akaibe, Bernard Agwanda, Thomas Briese, Jonathan H. Epstein, Peter Daszak, Charles E. Rupprecht, Edward C. Holmes, W. Ian Lipkin

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

Although there are over 1,150 bat species worldwide, the diversity of viruses harbored by bats has only recently come into focus as a result of expanded wildlife surveillance. Such surveys are of importance in determining the potential for novel viruses to emerge in humans, and for optimal management of bats and their habitats. To enhance our knowledge of the viral diversity present in bats, we initially surveyed 415 sera from African and Central American bats. Unbiased high-throughput sequencing revealed the presence of a highly diverse group of bat-derived viruses related to hepaciviruses and pegiviruses within the family Flaviridae. Subsequent PCR screening of 1,258 bat specimens collected worldwide indicated the presence of these viruses also in North America and Asia. A total of 83 bat-derived viruses were identified, representing an infection rate of nearly 5%. Evolutionary analyses revealed that all known hepaciviruses and pegiviruses, including those previously documented in humans and other primates, fall within the phylogenetic diversity of the bat-derived viruses described here. The prevalence, unprecedented viral biodiversity, phylogenetic divergence, and worldwide distribution of the bat-derived viruses suggest that bats are a major and ancient natural reservoir for both hepaciviruses and pegiviruses and provide insights into the evolutionary history of hepatitis C virus and the human GB viruses.
Original languageAmerican English
Pages (from-to)8194-8199
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
DOIs
StatePublished - 14 May 2013
Externally publishedYes

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    Quan, P. L., Firth, C., Conte, J. M., Williams, S. H., Zambrana-Torrelio, C. M., Anthony, S. J., Ellison, J. A., Gilbert, A. T., Kuzmin, I. V., Niezgoda, M., Osinubi, M. O. V., Recuenco, S., Markotter, W., Breiman, R. F., Kalemba, L., Malekani, J., Lindblade, K. A., Rostal, M. K., Ojeda-Flores, R., ... Lipkin, W. I. (2013). Bats are a major natural reservoir for hepaciviruses and pegiviruses. Proceedings of the National Academy of Sciences of the United States of America, 8194-8199. https://doi.org/10.1073/pnas.1303037110