Bioavailability and nervous tissue distribution of pyrethroid insecticide cyfluthrin in rats

José Luis Rodríguez, Irma Ares, Marta Martínez, María Rosa Martínez-Larrañaga, Arturo Anadón, María Aránzazu Martínez

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Toxicokinetics of cyfluthrin after single oral [20 mg/kg body weight (bw)] and intravenous (IV) (3 mg/kg bw) doses were studied in rats. Serial blood samples were obtained after oral and IV administration. Brain tissue samples were also collected after oral administration. Cyfluthrin concentrations in plasma and brain tissues (hypothalamus, striatum, hippocampus and frontal cortex) were quantified using liquid chromatography tandem mass spectrometry (LC/MS). Cyfluthrin disposition was best described by the use of a two-compartment open model. When given orally, plasma kinetics showed an extensive oral absorption of cyfluthrin and a slow elimination. The area under the concentration-time curve [AUC (0–24h)] and maximal plasma concentration (Cmax) were 6.11 ± 1.06 mg h/L and 0.385 ± 0.051 μg/mL, respectively; β phase elimination half-life (T1/2β) was (17.15 ± 1.67 h). Oral bioavailability was found to be 71.60 ± 12.36%. After oral administration, cyfluthrin was widely distributed to brain tissues. AUC (0–24h) was significant higher in all tested brain tissues than in plasma. The largest discrepancy was found for hypothalamus. AUC (0–24h), Cmax and T1/2β in hypothalamus were 19.36 ± 2.56 mg h/L, 1.21 ± 0.11 μg/g and 22.73 ± 1.60 h, respectively. Assuming the identified toxicokinetics parameters, this study serves to better understand mammalian toxicity of pyrethroid cyfluthrin and to design further studies to characterize its neurotoxicity.

Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalFood and Chemical Toxicology
Volume118
DOIs
StatePublished - Aug 2018

Bibliographical note

Funding Information:
This work was supported by Project Ref. S2013/ABI-2728 from Comunidad de Madrid, and Project Ref. RTA2015-00010-C03-03 from Ministerio de Economía, Industria y Competitividad. Spain.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Blood and central nervous system
  • Cyfluthrin
  • Pyrethroids
  • Toxicokinetics

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