Efeitos bioquímicos e histopatológicos da administração de diclofenaco e cetoprofeno na regeneração óssea

Translated title of the contribution: Biochemical and histopathological effects of diclofenac and ketoprofen administration on bone regeneration

Victor Chumpitaz-Cerrate, Lesly Karem Chávez Rimache, Siancas Aguirre Siancas, César Ivanovish Franco Quino, Eliberto Ruiz Ramirez, Carlos Erazo-Paredes

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the biochemical and histopathological effects of diclofenac and ketoprofen administration on bone regeneration in a calvarial defect model in rats. Material and Methods: The sample consisted of 108 Wistar rats that were randomly distributed in three groups, to which an osteotomy of 6 mm in diameter was performed in the calvaria. Group A (control) was given saline solution; Group B received ketoprofen 2 mg/kg and Group C received diclofenac 2 mg/kg. All treatments were administered intraperitoneally every 12 hours for 3 days. Bone regeneration was evaluated by biochemical (alkaline phosphatase and serum calcium) and histopathological (osteocyte and osteoblast cell count) characteristics at 15 and 30 days. Results: In the biochemical evaluation, alkaline phosphatase levels in the ketoprofen group were significantly lower compared to the diclofenac group at 15 and 30 days (p= 0.015 and p= 0.001; respectively). However, serum calcium levels did not show the difference between the study groups at 15 and 30 days (p= 0.42 and p= 0.81; respectively). In the histopathological analysis, the count of osteoblasts and osteocytes was significantly lower in the ketoprofen group compared to the diclofenac group at 15 and 30 days (p< 0.05). Conclusion: The administration of ketoprofen has negative biochemical and histopathological effects of greater intensity on bone regeneration compared to the administration of diclofenac.

Translated title of the contributionBiochemical and histopathological effects of diclofenac and ketoprofen administration on bone regeneration
Original languagePortuguese
Pages (from-to)1-8
Number of pages8
JournalBrazilian Dental Science
Volume24
Issue number3
DOIs
StatePublished - 1 Jul 2021

Bibliographical note

Funding Information:
Our gratitude to the National University of San Marcos (UNMSM) for providing us with financial support to carry out this research work.

Publisher Copyright:
© 2021, Universidade Estadual Paulista, Institute of Science and Technology of Sao Jose dos Campos. All rights reserved.

Keywords

  • Bone regeneration
  • Diclofenac
  • Ketoprofen
  • Nnon-steroidal anti-inflammatory agents
  • Rats

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