TY - JOUR
T1 - Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study
T2 - Study design and HPV DNA/p16INK4a status
AU - HEADLAcE Study Group
AU - Sichero, Laura
AU - Tagliabue, Marta
AU - Mota, Giana
AU - Ferreira, Silvaneide
AU - Nunes, Rafaella A.L.
AU - Castañeda, Carlos Arturo
AU - Castillo, Miluska
AU - Correa, Rita Mariel
AU - Perdomo, Sandra
AU - Rodríguez-Urrego, Paula A.
AU - Matos, Leandro Luongo
AU - Mohssen, Ansarin
AU - Gheit, Tarik
AU - Tommasino, Massimo
AU - Chiocca, Susanna
AU - Villa, Luisa Lina
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2022/1
Y1 - 2022/1
N2 - Background: Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods: HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16INK4a immunohistochemistry. Results: HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions: Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide.
AB - Background: Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods: HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16INK4a immunohistochemistry. Results: HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions: Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide.
KW - head and neck cancer
KW - human papillomavirus
KW - multinational study
KW - prevalence
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85122839302&partnerID=8YFLogxK
U2 - 10.1002/hed.26912
DO - 10.1002/hed.26912
M3 - Artículo
C2 - 34726297
AN - SCOPUS:85122839302
SN - 1043-3074
VL - 44
SP - 122
EP - 133
JO - Head and Neck
JF - Head and Neck
IS - 1
ER -