C ordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Juan Pedro Rojas-Armas, Jorge Luis Arroyo-Acevedo, Jose Manuel Ortiz Sanchez, Miriam Palomino-Pacheco, Oscar Herrera-Calderón, James Calva, Agustín Rojas-Armas, Hugo Jesús Justil-Guerrero, Américo Castro-Luna, Julio Hilario-Vargas

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to evaluate the chemopreventive effect of the ethanolic extract of Cordia lutea flowers (EECL) on N-methyl-N-nitrosourea-(MNU), cyproterone-, and testosterone-induced prostate cancer in rats. 40 Holtzman male rats were used and assigned to 5 groups (n = 8). In Group I, rats received normal saline (10 mL/Kg); Group II: rats were induced for prostate cancer with cyproterone, testosterone, and NMU; Groups III, IV, and V: rats received EECL daily, at doses of 50, 250, and 500 mg/kg body weight, respectively. After the period of treatment, animals were sacrificed by an overdose of pentobarbital and blood samples were collected for determination of prostate-specific antigen (PSA). The prostate was dissected and weighed accurately. The ventral lobe of the prostate was processed for histopathology analysis. The somatic prostate index decreased with EECL at dependent dose, from 0.34 ± 0.04 to 0.23 ± 0.05 (P<0.05). The PSA levels also decreased significantly at doses of 250 and 500 mg/kg. Histopathological analysis showed a decrease in the number of prostatic layers with high-grade prostatic intraepithelial neoplasia (HG-PIN) and low-grade prostatic intraepithelial neoplasia (LG-PIN) at the dose of 500 mg/kg. The ethanolic extract of Cordia lutea flowers had a chemopreventive effect on induced prostate cancer in rats.

Original languageEnglish
Article number5062942
JournalEvidence-based Complementary and Alternative Medicine
Volume2020
DOIs
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 Juan Pedro Rojas-Armas et al.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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