Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients

Raf Zaragoza, J. Pemán, G. Quindós, J. R. Iruretagoyena, M. S. Cuétara, P. Ramírez, M. D. Gómez, J. J. Camarena, A. Viudes, J. Pontón, S. Sancho, R. González, M. J. Giménez, M. Alkorta, J. Suárez, E. Martín-Mazuelos, M. J. Linares-Sicilia

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Abstract

The present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine the clinical significance and influence on mortality of Candida albicans germ tube-specific antibodies (CAGTA). There were 22 patients (41.5%) for whom the CAGTA results were positive, although none of had a blood culture positive for Candida. The intra-ICU mortality rate was significantly lower (p = 0.004) in CAGTA-positive patients (61.25 vs. 22.7%). Multivariate analysis confirmed that a positive CAGTA result was the only protective factor to be independently associated with ICU mortality (β coefficient = -0.3856; 95% confidence interval = -0.648 to -0.123). © 2009 The Authors Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases.
Original languageAmerican English
Pages (from-to)592-595
Number of pages4
JournalClinical Microbiology and Infection
DOIs
StatePublished - 1 Jan 2009
Externally publishedYes

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    Zaragoza, R., Pemán, J., Quindós, G., Iruretagoyena, J. R., Cuétara, M. S., Ramírez, P., Gómez, M. D., Camarena, J. J., Viudes, A., Pontón, J., Sancho, S., González, R., Giménez, M. J., Alkorta, M., Suárez, J., Martín-Mazuelos, E., & Linares-Sicilia, M. J. (2009). Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients. Clinical Microbiology and Infection, 592-595. https://doi.org/10.1111/j.1469-0691.2009.02794.x