Clinical subtypes and molecular characteristics of serrated polyposis syndrome

Carla Guarinos, Cristina Sánchez-Fortún, María Rodríguez-Soler, Lucía Pérez-Carbonell, Cecilia Egoavil, Miriam Juárez, Anna Serradesanferm, Luis Bujanda, Fernando Fernández-Bañares, Joaquín Cubiella, Luisa de-Castro, Ana Guerra, Elena Aguirre, Alberto Herreros-de-Tejada, Xavier Bessa, Maite Herráiz, José Carlos Marín-Gabriel, Judith Balmaña, Miriam Cuatrecasas, Francesc BalaguerAntoni Castells, José Luis Soto, Cristina Alenda, Artemio Payá, Rodrigo Jover

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31 Scopus citations

Abstract

BACKGROUND & AIMS: We investigated clinical and molecular differences between the different phenotypes of serrated polyposis syndrome (SPS) and the frequency of mutations in BRAF or KRAS in polyps from patients with SPS. METHODS: We collected data on clinical and demographic characteristics of 50 patients who fulfilled the criteria for SPS. Polymerase chain reaction and sequence analysis were used to identify BRAF and KRAS mutations in 432 polyps collected from 37 patients; we analyzed CpG island methylator phenotypes in 272 of these polyps. RESULTS: Fifteen patients (30%) had type 1 SPS and 35 had type 2 SPS. There were no significant differences in age at diagnosis, sex, smoking frequency, body mass index, or colorectal cancer predisposition between groups of patients, or in the pathologic or molecular characteristics of their polyps. A familial history of colorectal cancer or colonic polyps was reported more frequently by patients with type 2 SPS. BRAF mutations were found in 63% of polyps and KRAS mutations were found in 9.9%; 43.4% of polyps had the CpG island methylator phenotype-high phenotype. A per-patient analysis revealed that all patients had a BRAF or KRAS mutation in more than 25% of their polyps; 84.8% of patients had a mutation in BRAF or KRAS in more than 50% of their polyps. CONCLUSIONS: Except for a greater likelihood of familial history of colorectal cancer or colonic polyps in patients with type 2 SPS, we found no significant demographic, pathologic, or molecular differences between types 1 and 2 SPS. All patients had a BRAF or KRAS mutation in at least 25% of their polyps.© 2013 AGA Institute.
Original languageAmerican English
Pages (from-to)705-711
Number of pages7
JournalClinical Gastroenterology and Hepatology
DOIs
StatePublished - 1 Jun 2013
Externally publishedYes

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    Guarinos, C., Sánchez-Fortún, C., Rodríguez-Soler, M., Pérez-Carbonell, L., Egoavil, C., Juárez, M., Serradesanferm, A., Bujanda, L., Fernández-Bañares, F., Cubiella, J., de-Castro, L., Guerra, A., Aguirre, E., Herreros-de-Tejada, A., Bessa, X., Herráiz, M., Marín-Gabriel, J. C., Balmaña, J., Cuatrecasas, M., ... Jover, R. (2013). Clinical subtypes and molecular characteristics of serrated polyposis syndrome. Clinical Gastroenterology and Hepatology, 705-711. https://doi.org/10.1016/j.cgh.2012.12.045