Comparison of chemometric methods for assessing blending end-point by using NIR and Raman spectroscopy

Rubén Cueva-Mestanza, Celia Vargas-De-La-Cruz, Jesús Benites-Mena, Sixto Gonzalez-Elera, Faraat Ali

Research output: Contribution to journalArticlepeer-review


Blending is a critical stage in manufacturing. Therefore, a correct determination of final mixing point is necessary. In this work, vibration spectroscopic techniques, near infrared spectroscopy (NIR) and Raman spectroscopy are compared. This study has been carried out by means of a non-invasive monitoring of a blending process of a pharmaceutical blending. Difference between the Moving Block Average and Target spectrum (DMBA-TS) and Score Distance Analysis on the Main Component (PC-SDA), applying the latter in the NIR and Raman data. Different results were obtained with DMBA-ST and similar ones with PC-SDA, so although it is possible to follow the mixing by both NIR and Raman, it is necessary to take into account the method that is applied with each technique, since the characteristics of the spectra can affect the results obtained by the methods used to determine the final point of blending.

Original languageEnglish
JournalAnnals of Tropical Medicine and Public Health
Issue number10
StatePublished - Jun 2020
Externally publishedYes

Bibliographical note

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  • Blending end-point
  • End-point determination
  • NIR spectroscopy
  • No-invasive monitoring
  • Raman spectroscopy


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