TY - JOUR
T1 - Comparison of chemometric methods for assessing blending end-point by using NIR and Raman spectroscopy
AU - Cueva-Mestanza, Rubén
AU - Vargas-De-La-Cruz, Celia
AU - Benites-Mena, Jesús
AU - Gonzalez-Elera, Sixto
AU - Ali, Faraat
N1 - Publisher Copyright:
© 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Blending is a critical stage in manufacturing. Therefore, a correct determination of final mixing point is necessary. In this work, vibration spectroscopic techniques, near infrared spectroscopy (NIR) and Raman spectroscopy are compared. This study has been carried out by means of a non-invasive monitoring of a blending process of a pharmaceutical blending. Difference between the Moving Block Average and Target spectrum (DMBA-TS) and Score Distance Analysis on the Main Component (PC-SDA), applying the latter in the NIR and Raman data. Different results were obtained with DMBA-ST and similar ones with PC-SDA, so although it is possible to follow the mixing by both NIR and Raman, it is necessary to take into account the method that is applied with each technique, since the characteristics of the spectra can affect the results obtained by the methods used to determine the final point of blending.
AB - Blending is a critical stage in manufacturing. Therefore, a correct determination of final mixing point is necessary. In this work, vibration spectroscopic techniques, near infrared spectroscopy (NIR) and Raman spectroscopy are compared. This study has been carried out by means of a non-invasive monitoring of a blending process of a pharmaceutical blending. Difference between the Moving Block Average and Target spectrum (DMBA-TS) and Score Distance Analysis on the Main Component (PC-SDA), applying the latter in the NIR and Raman data. Different results were obtained with DMBA-ST and similar ones with PC-SDA, so although it is possible to follow the mixing by both NIR and Raman, it is necessary to take into account the method that is applied with each technique, since the characteristics of the spectra can affect the results obtained by the methods used to determine the final point of blending.
KW - Blending end-point
KW - End-point determination
KW - NIR spectroscopy
KW - No-invasive monitoring
KW - Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85092367357&partnerID=8YFLogxK
U2 - 10.36295/ASRO.2020.231043
DO - 10.36295/ASRO.2020.231043
M3 - Artículo
AN - SCOPUS:85092367357
SN - 1755-6783
VL - 23
JO - Annals of Tropical Medicine and Public Health
JF - Annals of Tropical Medicine and Public Health
IS - 10
ER -
