Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression. Results. The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21). Conclusions. The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.
|Translated title of the contribution||Connection between genetic polymorphism of interleukin-1beta with chronic periodontitis in Peruvian adults|
|Number of pages||6|
|Journal||Revista Peruana de Medicina de Experimental y Salud Publica|
|State||Published - 1 Jan 2018|
Bibliographical noteFunding Information:
El desarrollo de esta investigación contó con el apoyo económico del Fondo de Innovación de Ciencia y Tecnología FINCyT, Resolución Directoral N° 30-2008-PCM/ FINCyT, contrato N°001-FINCyT-PIBAP 2008 y se realizó en el Laboratorio II-5 de Genética Molecular del Centro de Investigación de Bioquímica y Nutrición de la Facultad de Medicina de la Universidad Nacional Mayor De San Marcos.
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