Contribution of topical antioxidants to maintain healthy skin—A review

Tércio Elyan Azevedo Martins, Claudinéia Aparecida Sales de Oliveira Pinto, Andressa Costa de Oliveira, Maria Valéria Robles Velasco, Arilmí Rosa Gorriti Guitiérrez, Martha Francisca Cosquillo Rafael, Jossimar Paúl Huamaní Tarazona, Mónica Guadalupe Retuerto-Figueroa

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The skin is constantly exposed to various environmental stresses, in particular to the damage caused by pollution and ultraviolet radiation (UV), and as a consequence, the horny extract can be negatively impacted by the harmful influence of some of its surface components. The mechanisms involved in the degradation processes promoted by UV radiation are driven by the direct absorption of radiation via cellular chromophores, the formation of excited states and the consequent chemical reactions, or even by the photosensitization mechanisms, in which UV light is absorbed by the sensitizers that are excited and their reactions promote the formation of reactive oxygen species (ROS). The mechanisms of polluting agents are not yet fully understood, however, they indicate that one of the main mechanisms involved is oxidative stress by lipid peroxidation, with the ability to promote damage to the composition of sebum, the quality of the stratum corneum and also, promote aging skin. Recent studies demonstrate the potential of antioxidant agents, with an emphasis on products of natural origin, which try to promote the maintenance of the physiological balance of the skin.

Original languageEnglish
Article number27
Pages (from-to)1-17
Number of pages17
JournalScientia Pharmaceutica
Issue number2
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Antioxidant
  • Permeation
  • Pollution
  • Skin
  • Solar radiation


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