Costo-efectividad de dos terapias antivirales para hepatitis B crónica en el perú: Entecavir y tenofovir

Translated title of the contribution: Cost-effectiveness of two antiviral therapies for chronic hepatitis B in Peru: Entecavir and tenofovir

Rafael Bolaños-Díaz, Romina A. Tejada, César Sanabria, Seimer Escobedo-Palza

Research output: Contribution to journalArticlepeer-review

Abstract

Objetives. To compare in terms of cost-effectiveness to entecavir (ETV) and tenofovir (TDF) in the treatment of hepatitis B virus (HBV) in public hospitals in Peru. Materials and methods. We structured a Markov model. We define effectiveness adjusted life years for quality (QALY). We include the direct costs of treatment in soles from the perspective of the Ministry of Health of Peru. We estimate the relationship between cost and effectiveness ratios (ICER). We performed sensitivity analyzes considering a range of willingness to pay (WTP) from one to three times the Gross Domestic Product (GDP) per capita, and a tornado analysis regarding Monetary Net Profit (BMN) or ICER. Results. Treatment with TDF is more effective and less expensive than ETV. The ETV had a cost per QALY of PEN 4482, and PEN 1526 TDF. The PTO maintains a progressively larger with increasing WTP BMN. The discount rate was the only variable with a significant effect on model uncertainty. Conclusion: Treatment with TDF is more cost-effective than ETV in public hospitals in Peru.

Translated title of the contributionCost-effectiveness of two antiviral therapies for chronic hepatitis B in Peru: Entecavir and tenofovir
Original languageSpanish
Pages (from-to)377-385
Number of pages9
JournalRevista Peruana de Medicina de Experimental y Salud Publica
Volume34
Issue number3
DOIs
StatePublished - 1 Jul 2017

Bibliographical note

Publisher Copyright:
© 2017, Instituto Nacional de Salud. All rights reserved.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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