TY - JOUR
T1 - Efecto citotóxico del extracto metanólico de tres ecotipos de Lepidium peruvianum Chacón sobre líneas celulares HeLa y HT-29
AU - Alzamora, Libertad
AU - Colona Vallejos, Erasmo Honorio
AU - De Mesa, Nuria Acero
AU - De Mera, Antonio Galán
AU - Muñoz-Mingarro, Dolores
AU - Linares, Francisco
AU - Domínguez, María Teresa
AU - Alvarez, Evelyn
N1 - Publisher Copyright:
© 2017 Facultad de Ciencias Biológicas UNMSM.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2007/7
Y1 - 2007/7
N2 - The search of natural compound with cytotoxic and antitumoural activities is one of the current priorities of the fight against the cancer; being necessary to analyze new extracts of plants. The objective in this paper was to evaluate the cytotoxic activity of the methanolic extract (ME) of the black, purple and yellow ecotypes of Lepidium peruvianum, Chacón (at present Lepidium meyenii Walp.), Maca, on the cellular lines HeLa (Human Epithelial Carcinoma) and HT-29 (Human Colon Adenocarcinoma). For the cellular line HT-29, the inhibitory concentration of 50% of the cellular growth (IC50) with the black, purple and yellow ecotypes was of 8,32 mg/ml, 9,28 mg/ml and 0,487 mg/ml, respectively; while for the cellular line HeLa was of 2,4 mg/ml, 1,93 mg/ml and 0,66 mg/ml respectively. Additionally, ME of the yellow ecotype was evaluated with two years of storage (10°C) determining an IC50 4,29 mg/ml for HT-29 and 4,17 mg/ml for HeLa. We concludes that the cytotoxic effect of the yellow ecotype on HT-29 and HeLa went high to the showed by the black and purple ecotypes; that the most sensitive cellular line to the yellow, black and purple ecotypes is HeLa, and that the ME of the yellow ecotype conserved its cytotoxic properties in spite of the time of storage.
AB - The search of natural compound with cytotoxic and antitumoural activities is one of the current priorities of the fight against the cancer; being necessary to analyze new extracts of plants. The objective in this paper was to evaluate the cytotoxic activity of the methanolic extract (ME) of the black, purple and yellow ecotypes of Lepidium peruvianum, Chacón (at present Lepidium meyenii Walp.), Maca, on the cellular lines HeLa (Human Epithelial Carcinoma) and HT-29 (Human Colon Adenocarcinoma). For the cellular line HT-29, the inhibitory concentration of 50% of the cellular growth (IC50) with the black, purple and yellow ecotypes was of 8,32 mg/ml, 9,28 mg/ml and 0,487 mg/ml, respectively; while for the cellular line HeLa was of 2,4 mg/ml, 1,93 mg/ml and 0,66 mg/ml respectively. Additionally, ME of the yellow ecotype was evaluated with two years of storage (10°C) determining an IC50 4,29 mg/ml for HT-29 and 4,17 mg/ml for HeLa. We concludes that the cytotoxic effect of the yellow ecotype on HT-29 and HeLa went high to the showed by the black and purple ecotypes; that the most sensitive cellular line to the yellow, black and purple ecotypes is HeLa, and that the ME of the yellow ecotype conserved its cytotoxic properties in spite of the time of storage.
KW - Cytotoxicity
KW - Lepidium meyenii Walp.
KW - Lepidium peruvianum
KW - Maca
KW - Methanolic extract
KW - Peruvian traditional medicine
UR - http://www.scopus.com/inward/record.url?scp=85045004873&partnerID=8YFLogxK
M3 - Artículo
AN - SCOPUS:85045004873
VL - 13
SP - 219
EP - 221
JO - Revista Peruana de Biologia
JF - Revista Peruana de Biologia
SN - 1561-0837
IS - 3
ER -