Deciphering the focal role of endostatin in Alzheimer’s disease

Dapinder Kaur, Tapan Behl, Sridevi Chigurupati, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Vishnu Nayak Badavath, Celia Vargas-De-La-Cruz, Saurabh Bhatia, Ahmed Al-Harrasi, Abhijit Dey, Lotfi Aleya, Simona Bungau

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer’s disease (AD) is a paramount chronic neurodegenerative condition that has been affecting elderly people since the 1900s. It causes memory loss, disorientation, and poor mental function. AD is considered to be one of the most serious problems that dementia sufferers face. Despite extensive investigation, the pathological origin of Alzheimer’s disease remains a mystery. The amyloid cascade theory and the vascular hypothesis, which stresses the buildup of Aβ plaques, have dominated research into dementia and aging throughout history. However, research into this task failed to yield the long-awaited therapeutic miracle lead for Alzheimer’s disease. Perhaps a hypothetical fragility in the context of Alzheimer’s disease was regarded as a state distinct from aging in general, as suggested by the angiogenesis hypothesis, which suggests that old age is one state associated with upregulation of angiogenic growth factors, resulting in decreased microcirculation throughout the body. There has also been evidence that by controlling or inhibiting the components involved in the sequence of events that cause angiogenesis, there is a visible progression in AD patients. In Alzheimer’s disease, one such antiangiogenic drug is being used.

Original languageEnglish
JournalEnvironmental Science and Pollution Research
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • Alzheimer’s disease
  • Angiogenesis
  • Antiangiogenic factors
  • Collagen XVIII
  • Endostatin
  • Pro-angiogenic factors

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