Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru

Zhiyong Zhou, Sean M. Griffing, Alexandre Macedo De Oliveira, Andrea M. McCollum, Wilmer Marquino Quezada, Nancy Arrospide, Ananias A. Escalante, Venkatachalam Udhayakumar

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Abstract

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.

Original languageEnglish
Pages (from-to)739-741
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number2
DOIs
StatePublished - Feb 2008

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