TY - JOUR
T1 - Demographic and Clinical Features of ANCA-Associated Vasculitides in a Peruvian Tertiary Center
AU - Pimentel-Quiroz, Victor R.
AU - Sánchez-Torres, Alfredo
AU - Acevedo-Vásquez, Eduardo
AU - Gamboa-Cárdenas, Rocío V.
AU - Reátegui-Sokolova, Cristina
AU - Medina-Chinchón, Mariela
AU - Zevallos, Francisco
AU - Noriega-Zapata, Erika
AU - Alfaro-Lozano, José
AU - Cucho-Venegas, Jorge M.
AU - Sánchez-Schwartz, César
AU - Rodríguez-Bellido, Zoila
AU - Perich-Campos, Risto
AU - Pastor-Asurza, César A.
AU - Alarcón, Graciela S.
AU - Ugarte-Gil, Manuel F.
N1 - Publisher Copyright:
© 2020 Wolters Kluwer Health, Inc.
PY - 2021
Y1 - 2021
N2 - Aim: The aim of this study was to identify the demographic and clinical features of patients with ANCA-associated vasculitides (AAVs) in a Peruvian tertiary referral hospital. Methods: Medical records of patients with AAVaccording to classification criteria or diagnosed by an experienced rheumatologist, and covering the period between January 1990 and December 2019, were reviewed. Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and renal-limited vasculitis (RLV) were included. Demographic factors (age at diagnosis, sex), disease duration, clinical manifestations (per organ involvement), creatinine level at diagnosis (milligram per deciliter), ANCA status, diagnosis, 2009 Five Factor Score, disease categorization, and treatment were recorded. Results: Two hundred twelve patients were included. Their female-to-male ratio was 1.9:1 (139 [65.6%]/73 [34.4%]), and their mean (SD) age at diagnosis was 59.2 (12.5) years. One hundred fifty-eight patients (74.5%) hadMPA, 42 (19.8%) GPA, 7 (3.3%) RLV, and 5 (2.4%) EGPA. Neurological, lung, and renal involvements were the most frequently affected systems. Myeloperoxidase preferentially occurred in MPA (82.5%), whereas proteinase 3 did occur in GPA (79.5%). Microscopic polyangiitis patients were older (61.1 [11.5] years). Female sex predominated in MPA and RLV (2.4:1 and 6:1, respectively), but the opposite was the case for EGPA (1:4). Ear-nose-throat and ocular involvement were more frequent in GPA (both p's < 0.001), and neurological and cardiovascular involvement were more frequent in EGPA (p < 0.001 and p = 0.002, respectively). Conclusions: This is one of the largest series of AAV patients in Latin America. Overall, female sex predominated. Microscopic polyangiitis was themost frequent AAV, andmyeloperoxidase-ANCAwas themost frequent antibody in Peruvian AAV population.
AB - Aim: The aim of this study was to identify the demographic and clinical features of patients with ANCA-associated vasculitides (AAVs) in a Peruvian tertiary referral hospital. Methods: Medical records of patients with AAVaccording to classification criteria or diagnosed by an experienced rheumatologist, and covering the period between January 1990 and December 2019, were reviewed. Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and renal-limited vasculitis (RLV) were included. Demographic factors (age at diagnosis, sex), disease duration, clinical manifestations (per organ involvement), creatinine level at diagnosis (milligram per deciliter), ANCA status, diagnosis, 2009 Five Factor Score, disease categorization, and treatment were recorded. Results: Two hundred twelve patients were included. Their female-to-male ratio was 1.9:1 (139 [65.6%]/73 [34.4%]), and their mean (SD) age at diagnosis was 59.2 (12.5) years. One hundred fifty-eight patients (74.5%) hadMPA, 42 (19.8%) GPA, 7 (3.3%) RLV, and 5 (2.4%) EGPA. Neurological, lung, and renal involvements were the most frequently affected systems. Myeloperoxidase preferentially occurred in MPA (82.5%), whereas proteinase 3 did occur in GPA (79.5%). Microscopic polyangiitis patients were older (61.1 [11.5] years). Female sex predominated in MPA and RLV (2.4:1 and 6:1, respectively), but the opposite was the case for EGPA (1:4). Ear-nose-throat and ocular involvement were more frequent in GPA (both p's < 0.001), and neurological and cardiovascular involvement were more frequent in EGPA (p < 0.001 and p = 0.002, respectively). Conclusions: This is one of the largest series of AAV patients in Latin America. Overall, female sex predominated. Microscopic polyangiitis was themost frequent AAV, andmyeloperoxidase-ANCAwas themost frequent antibody in Peruvian AAV population.
KW - ANCA-associated vasculitides
KW - Latin America
KW - epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85116958774&partnerID=8YFLogxK
U2 - 10.1097/RHU.0000000000001595
DO - 10.1097/RHU.0000000000001595
M3 - Artículo
C2 - 33044385
AN - SCOPUS:85116958774
SN - 1076-1608
VL - 27
SP - S246-S251
JO - Journal of Clinical Rheumatology
JF - Journal of Clinical Rheumatology
IS - 6 S
ER -