Determinación de la temperatura de respuesta nociceptiva sobre la cola de ratones albinos de la cepa Balb/c

Translated title of the contribution: Determination of the temperature causing a nociceptive response in the tail of albino BALB/c mice

E. E. Aguirre Siancas, N. M. Lam Figueroa, J. C. Delgado Rios, E. Ruiz Ramirez, O. S. Portilla Flores, L. J. Crispín Huamaní, L. Alarcón Velásquez

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Introduction: Designs for determining nociceptive response in rodents are of great use in neurology and experimental neuroscience. Immersing mice's tails in warm water is one of the most widely used procedures to evaluate this response; however, a wide range of temperatures are used in different studies. Knowing the temperature that produces a powerful nociceptive response in the tail of BALB/c mice is extremely useful. Methods: Eight 2-month-old male BALB/c mice were used. A 14-cm high beaker was filled with water up to 13 cm. The animals’ tails were immersed in the container with a starting temperature of 36 °C. The water temperature was raised in 1 °C increments until we identified the temperatures that produced nociceptive responses. That response was determined by counting the time taken before the mouse shook its tail to remove it from the water. Results: Six of the 8 mice began shaking their tails at the temperature of 51 °C. All animals removed their tails from the water at the temperatures of 54 °C, 55 °C, and 56 °C, taking a mean time of 8.54, 7.99, and 5.33 seconds, respectively. ANOVA applied to the response times for each of the 3 temperatures indicated revealed a value of F=2.8 (P=.123). Conclusions: The response time was statistically similar for the temperatures of 54 °C, 55 °C, and 56 °C; however, the data were less dispersed for the latter temperature.

Translated title of the contributionDetermination of the temperature causing a nociceptive response in the tail of albino BALB/c mice
Original languageSpanish
Pages (from-to)584-588
Number of pages5
Issue number8
StatePublished - Oct 2021

Bibliographical note

Funding Information:
We are thankful to Ministry of Science, Technology and Environment of the Government of Malaysia for generously funding the research, under the Research University Grant Project UKM-GUP-PI-08-34-081 and FRGS/1/2012/SS07/UKM/01/3.

Publisher Copyright:
© 2018 Sociedad Española de Neurología


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