Development of a microcomposite with single-walled carbon nanotubes and Nd 2 O 3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry

Verónica Arancibia, Johisner Penagos-Llanos, Edgar Nagles, Olimpo García-Beltrán, John J. Hurtado

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

This study presents for the first time a new composite of carbon paste (CP), single-walled carbon nanotubes (SWCNTs) and Nd 2 O 3 (Nd OX ). This versatile composite (Nd OX -SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). The newly formed surface was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 µA with CPE and Nd OX -SWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 µmol/L with Nd OX -SWCNT/CPE and 0.50 µmol/L with SWCNT/CPE. The relative standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalJournal of Pharmaceutical Analysis
Volume9
Issue number1
DOIs
StatePublished - Feb 2019

Bibliographical note

Funding Information:
The author J.J. Hurdato is grateful the Universidad de los Andes for financial support from the Interfaculty project and the Faculty of Sciences. E. Nagles and O. García-Beltrán thank the financial support of the Universidad de Ibagué (project 18-541-INT ) and COLCIENCIAS (project 130774559056 ). They are gratefully acknowledged.

Publisher Copyright:
© 2018 Xi'an Jiaotong University

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Neodymium (III) Oxide
  • Paracetamol
  • Pharmaceutical dosage
  • Single-walled carbon nanotubes

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