Development of a microcomposite with single-walled carbon nanotubes and Nd                         2                         O                         3                          for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry

Verónica Arancibia; Johisner Penagos-Llanos; Edgar Nagles; Olimpo García-Beltrán; John J. Hurtado

doi:10.1016/j.jpha.2018.11.005

Development of a microcomposite with single-walled carbon nanotubes and Nd ₂ O ₃ for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry

Verónica Arancibia, Johisner Penagos-Llanos, Edgar Nagles, Olimpo García-Beltrán, John J. Hurtado

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

This study presents for the first time a new composite of carbon paste (CP), single-walled carbon nanotubes (SWCNTs) and Nd ₂ O ₃ (Nd _OX ). This versatile composite (Nd _OX -SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). The newly formed surface was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 µA with CPE and Nd _OX -SWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 µmol/L with Nd _OX -SWCNT/CPE and 0.50 µmol/L with SWCNT/CPE. The relative standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.

Original language	English
Pages (from-to)	62-69
Number of pages	8
Journal	Journal of Pharmaceutical Analysis
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.jpha.2018.11.005
State	Published - Feb 2019

Bibliographical note

Funding Information:
The author J.J. Hurdato is grateful the Universidad de los Andes for financial support from the Interfaculty project and the Faculty of Sciences. E. Nagles and O. García-Beltrán thank the financial support of the Universidad de Ibagué (project 18-541-INT ) and COLCIENCIAS (project 130774559056 ). They are gratefully acknowledged.

Publisher Copyright:
© 2018 Xi'an Jiaotong University

Keywords

Neodymium (III) Oxide
Paracetamol
Pharmaceutical dosage
Single-walled carbon nanotubes

Access to Document

10.1016/j.jpha.2018.11.005

Cite this

Arancibia, V., Penagos-Llanos, J., Nagles, E., García-Beltrán, O., & Hurtado, J. J. (2019). Development of a microcomposite with single-walled carbon nanotubes and Nd ₂ O ₃ for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry Journal of Pharmaceutical Analysis, 9(1), 62-69. https://doi.org/10.1016/j.jpha.2018.11.005

Arancibia, Verónica ; Penagos-Llanos, Johisner ; Nagles, Edgar et al. / Development of a microcomposite with single-walled carbon nanotubes and Nd ₂ O ₃ for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry In: Journal of Pharmaceutical Analysis. 2019 ; Vol. 9, No. 1. pp. 62-69.

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title = " Development of a microcomposite with single-walled carbon nanotubes and Nd 2 O 3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry ",

abstract = " This study presents for the first time a new composite of carbon paste (CP), single-walled carbon nanotubes (SWCNTs) and Nd 2 O 3 (Nd OX ). This versatile composite (Nd OX -SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). The newly formed surface was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 µA with CPE and Nd OX -SWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 µmol/L with Nd OX -SWCNT/CPE and 0.50 µmol/L with SWCNT/CPE. The relative standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.",

keywords = "Neodymium (III) Oxide, Paracetamol, Pharmaceutical dosage, Single-walled carbon nanotubes",

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Arancibia, V, Penagos-Llanos, J, Nagles, E, García-Beltrán, O & Hurtado, JJ 2019, ' Development of a microcomposite with single-walled carbon nanotubes and Nd ₂ O ₃ for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry ', Journal of Pharmaceutical Analysis, vol. 9, no. 1, pp. 62-69. https://doi.org/10.1016/j.jpha.2018.11.005

Development of a microcomposite with single-walled carbon nanotubes and Nd ₂ O ₃ for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry . / Arancibia, Verónica; Penagos-Llanos, Johisner; Nagles, Edgar et al.
In: Journal of Pharmaceutical Analysis, Vol. 9, No. 1, 02.2019, p. 62-69.

Research output: Contribution to journal › Article › peer-review

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AU - Arancibia, Verónica

AU - Penagos-Llanos, Johisner

AU - Nagles, Edgar

AU - García-Beltrán, Olimpo

AU - Hurtado, John J.

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KW - Neodymium (III) Oxide

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Arancibia V, Penagos-Llanos J, Nagles E, García-Beltrán O, Hurtado JJ. Development of a microcomposite with single-walled carbon nanotubes and Nd ₂ O ₃ for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry Journal of Pharmaceutical Analysis. 2019 Feb;9(1):62-69. doi: 10.1016/j.jpha.2018.11.005