TY - JOUR
T1 - Development of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes
T2 - Synthesis and biological activity evaluations
AU - Murcia, Ricardo A.
AU - Leal, Sandra M.
AU - Roa, Martha V.
AU - Nagles, Edgar
AU - Muñoz-Castro, Alvaro
AU - Hurtado, John J.
N1 - Publisher Copyright:
© 2018 by the authors.
PY - 2018/8/13
Y1 - 2018/8/13
N2 - In this work, six complexes (2-7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3-7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL-1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.
AB - In this work, six complexes (2-7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3-7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL-1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.
KW - Antibacterial activity
KW - Antifungal activity
KW - Cobalt(II) and chromium(III) complexes
KW - Triazole ligands
UR - http://www.scopus.com/inward/record.url?scp=85053619370&partnerID=8YFLogxK
U2 - 10.3390/molecules23082013
DO - 10.3390/molecules23082013
M3 - Artículo
C2 - 30104466
AN - SCOPUS:85053619370
SN - 1420-3049
VL - 23
JO - Molecules
JF - Molecules
IS - 8
M1 - 2013
ER -