Development of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes: Synthesis and biological activity evaluations

Ricardo A. Murcia, Sandra M. Leal, Martha V. Roa, Edgar Nagles, Alvaro Muñoz-Castro, John J. Hurtado

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Abstract

In this work, six complexes (2-7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3-7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL-1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.

Original languageEnglish
Article number2013
JournalMolecules
Volume23
Issue number8
DOIs
StatePublished - 13 Aug 2018

Bibliographical note

Funding Information:
The authors express their thanks to the Universidad de los Andes for the financial support from the Interfaculty project and the Faculty of Sciences. We thank the reviewers and editor for their useful comments.

Publisher Copyright:
© 2018 by the authors.

Keywords

  • Antibacterial activity
  • Antifungal activity
  • Cobalt(II) and chromium(III) complexes
  • Triazole ligands

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