TY - JOUR
T1 - Diagnosis of cystic echinococcosis, central peruvian highlands
AU - Gavidia, Cesar M.
AU - Gonzalez, Armando E.
AU - Zhang, Wenbao
AU - McManus, Donald P.
AU - Lopera, Luis
AU - Ninaquispe, Berenice
AU - Garcia, Hector H.
AU - Rodríguez, Silvia
AU - Verastegui, Manuela
AU - Calderon, Carmen
AU - Pan, William K.Y.
AU - Gilman, Robert H.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.
AB - We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=38949188953&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=38949188953&origin=inward
U2 - 10.3201/eid1402.061101
DO - 10.3201/eid1402.061101
M3 - Article
SN - 1080-6040
SP - 260
EP - 266
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
ER -
