Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons

Vitaliano A. Cama, Jennifer M. Ross, Sara Crawford, Vivian Kawai, Raul Chavez-Valdez, Daniel Vargas, Aldo Vivar, Eduardo Ticona, Marco Ñavincopa, John Williamson, Ynes Ortega, Robert H. Gilman, Caryn Bern, Lihua Xiao

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202 Scopus citations


We performed a cross-sectional study to determine the epidemiology of Cryptosporidium in human immunodeficiency virus (HIV)-infected persons at 3 diagnostic levels: microscopy, genotypes of Cryptosporidium, and subtype families of C. hominis and C. parvum. The study enrolled 2490 HIV-infected persons in Lima, Peru, and 230 were microscopy positive for Cryptosporidium infection. Specimens from 193 participants were available for genotyping. They had C. hominis (141 persons), C. parvum (22 persons), C. meleagridis (17 persons), C. canis (6 persons), C. felis (6 persons), and C. suis (1 person) infection. Although microscopy results showed that Cryptosporidium infections were associated with diarrhea, only infections with C. canis, C. felis, and subtype family Id of C. hominis were associated with diarrhea, and infection with C. parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations.

Original languageEnglish
Pages (from-to)684-691
Number of pages8
JournalJournal of Infectious Diseases
Issue number5
StatePublished - 1 Sep 2007

Bibliographical note

Funding Information:
Financial support: Opportunistic Infections Working Group of the Centers for Disease Control and Prevention (CDC); RG-ER Fund; National Institute for Allergy and Infectious Disease, National Institutes of Health (projects 5P01AI051976-04 and 5R21AI059661-02 to R.H.G. and V.A.C.); Division of Parasitic Diseases, CDC (Research Participation Program appointment to S.C. administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the CDC).


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