Alkenylboronic acids have shown important biological activities that contribute to neuroprotection. We have determined their influence on the β-amyloid (βA) aggregation process, β-secretase and acethylcholinesterase activities on cell-free systems, on the redox and lipid peroxidation status, and on the vulnerability to apoptotic death in an APPswe neuroblastoma cell line, before and after hydrogen peroxide treatment. We have discovered that 2-arylvinylboronic acids and some of their esters possess a set of properties which makes them highly useful as neuroprotective agents affecting multiple biological targets involved in AD. These properties are not paralleled by the related 2-arylboronic acids.
Bibliographical noteFunding Information:
This work was supported by grant CTQ2010-6170 from the Ministerio de Economía y Competitividad from the government of Spain. We thank Fundación Folch for a pre-doctoral grant to K. J.-A.
Copyright 2013 Elsevier B.V., All rights reserved.
- Boronic acids
- Lipid peroxidation
- β-Amyloid fibrillogenesis