Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment

Cristina Guerra-Giraldez; Miguel Marzal; Carla Cangalaya; Diana Balboa; Miguel Ángel Orrego; Adriana Paredes; Eloy Gonzales-Gustavson; Gianfranco Arroyo; Hector H. García; Armando E. González; Siddhartha Mahanty; Theodore E. Nash

doi:10.1016/j.exppara.2013.05.005

Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment

Cristina Guerra-Giraldez, Miguel Marzal, Carla Cangalaya, Diana Balboa, Miguel Ángel Orrego, Adriana Paredes, Eloy Gonzales-Gustavson, Gianfranco Arroyo, Hector H. García, Armando E. González, Siddhartha Mahanty, Theodore E. Nash

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120. h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.

Original language	English
Pages (from-to)	443-446
Number of pages	4
Journal	Experimental Parasitology
Volume	134
Issue number	4
DOIs	https://doi.org/10.1016/j.exppara.2013.05.005
State	Published - Aug 2013

Bibliographical note

Funding Information:
We thank Valentina Salas for valuable assistance at the preliminary stage, also Teresa López and Linda Gallegos for help at the veterinary facilities. This work was supported in part by an intramural Research Program of the National Institutes of Allergy and Infectious Diseases.

Keywords

Blood-brain barrier
Neurocysticercosis
Praziquantel
Taenia solium

Access to Document

10.1016/j.exppara.2013.05.005

Cite this

Guerra-Giraldez, C., Marzal, M., Cangalaya, C., Balboa, D., Orrego, M. Á., Paredes, A., Gonzales-Gustavson, E., Arroyo, G., García, H. H., González, A. E., Mahanty, S., & Nash, T. E. (2013). Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment. Experimental Parasitology, 134(4), 443-446. https://doi.org/10.1016/j.exppara.2013.05.005

@article{0cb8aa3f5ef341ff93aed2d3ac370540,

title = "Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment",

abstract = "Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120. h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.",

keywords = "Blood-brain barrier, Neurocysticercosis, Praziquantel, Taenia solium",

author = "Cristina Guerra-Giraldez and Miguel Marzal and Carla Cangalaya and Diana Balboa and Orrego, {Miguel {\'A}ngel} and Adriana Paredes and Eloy Gonzales-Gustavson and Gianfranco Arroyo and Garc{\'i}a, {Hector H.} and Gonz{\'a}lez, {Armando E.} and Siddhartha Mahanty and Nash, {Theodore E.}",

note = "Funding Information: We thank Valentina Salas for valuable assistance at the preliminary stage, also Teresa L{\'o}pez and Linda Gallegos for help at the veterinary facilities. This work was supported in part by an intramural Research Program of the National Institutes of Allergy and Infectious Diseases.",

year = "2013",

month = aug,

doi = "10.1016/j.exppara.2013.05.005",

language = "Ingl{\'e}s",

volume = "134",

pages = "443--446",

journal = "Experimental Parasitology",

issn = "0014-4894",

publisher = "Academic Press Inc.",

number = "4",

}

Guerra-Giraldez, C, Marzal, M, Cangalaya, C, Balboa, D, Orrego, MÁ, Paredes, A, Gonzales-Gustavson, E, Arroyo, G, García, HH, González, AE, Mahanty, S & Nash, TE 2013, 'Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment', Experimental Parasitology, vol. 134, no. 4, pp. 443-446. https://doi.org/10.1016/j.exppara.2013.05.005

TY - JOUR

T1 - Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment

AU - Guerra-Giraldez, Cristina

AU - Marzal, Miguel

AU - Cangalaya, Carla

AU - Balboa, Diana

AU - Orrego, Miguel Ángel

AU - Paredes, Adriana

AU - Gonzales-Gustavson, Eloy

AU - Arroyo, Gianfranco

AU - García, Hector H.

AU - González, Armando E.

AU - Mahanty, Siddhartha

AU - Nash, Theodore E.

N1 - Funding Information: We thank Valentina Salas for valuable assistance at the preliminary stage, also Teresa López and Linda Gallegos for help at the veterinary facilities. This work was supported in part by an intramural Research Program of the National Institutes of Allergy and Infectious Diseases.

PY - 2013/8

Y1 - 2013/8

N2 - Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120. h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.

AB - Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120. h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.

KW - Blood-brain barrier

KW - Neurocysticercosis

KW - Praziquantel

KW - Taenia solium

UR - http://www.scopus.com/inward/record.url?scp=84878915948&partnerID=8YFLogxK

U2 - 10.1016/j.exppara.2013.05.005

DO - 10.1016/j.exppara.2013.05.005

M3 - Artículo

C2 - 23684909

AN - SCOPUS:84878915948

SN - 0014-4894

VL - 134

SP - 443

EP - 446

JO - Experimental Parasitology

JF - Experimental Parasitology

IS - 4

ER -

Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this