Distribution of tumor-infiltrating immune cells in glioblastoma

Enrique Orrego, Carlos A. Castaneda, Miluska Castillo, Luis A. Bernabe, Sandro Casavilca, Arnab Chakravarti, Wei Meng, Pamela Garcia-Corrochano, Maria R. Villa-Robles, Rocio Zevallos, Omar Mejia, Pedro Deza, Carolina Belmar-Lopez, Luis Ojeda

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

AIM: Evaluation of features related to infiltrating immune cell level in glioblastoma. METHODS: Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis. RESULTS: CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest density. Higher CD4+ was associated with unmethylated MGMT (p = 0.016). Higher CD8+ was associated with larger tumoral size (p = 0.027). Higher CD163+ was associated with higher age (p = 0.044) and recursive partitioning analysis = 4. Women (p < 0.05), total resection (p < 0.05), MGMT-methylation (p < 0.001), radiotherapy (p < 0.001), chemotherapy (p < 0.001) and lower CD4+ (p < 0.05) were associated with longer overall survival. CONCLUSION: Macrophages are more frequent than TILs. Some subsets are associated with clinical features.
Original languageAmerican English
Pages (from-to)CNS21
Number of pages1
JournalCNS oncology
DOIs
StatePublished - 1 Dec 2018
Externally publishedYes

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    Orrego, E., Castaneda, C. A., Castillo, M., Bernabe, L. A., Casavilca, S., Chakravarti, A., Meng, W., Garcia-Corrochano, P., Villa-Robles, M. R., Zevallos, R., Mejia, O., Deza, P., Belmar-Lopez, C., & Ojeda, L. (2018). Distribution of tumor-infiltrating immune cells in glioblastoma. CNS oncology, CNS21. https://doi.org/10.2217/cns-2017-0037