Distribution of tumor-infiltrating immune cells in glioblastoma

Enrique Orrego, Carlos Arturo Castañeda Altamirano, Miluska Castillo, Luis A. Bernabe, Sandro Casavilca, Arnab Chakravarti, Wei Meng, Pamela Garcia-Corrochano, Maria R. Villa-Robles, Rocio Zevallos, Omar Mejia, Pedro Deza, Carolina Belmar-Lopez, Luis Ojeda

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

AIM: Evaluation of features related to infiltrating immune cell level in glioblastoma. METHODS: Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis. RESULTS: CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest density. Higher CD4+ was associated with unmethylated MGMT (p = 0.016). Higher CD8+ was associated with larger tumoral size (p = 0.027). Higher CD163+ was associated with higher age (p = 0.044) and recursive partitioning analysis = 4. Women (p < 0.05), total resection (p < 0.05), MGMT-methylation (p < 0.001), radiotherapy (p < 0.001), chemotherapy (p < 0.001) and lower CD4+ (p < 0.05) were associated with longer overall survival. CONCLUSION: Macrophages are more frequent than TILs. Some subsets are associated with clinical features.

Original languageEnglish
Pages (from-to)CNS21
JournalCNS oncology
Volume7
Issue number4
DOIs
StatePublished - 1 Dec 2018
Externally publishedYes

Keywords

  • biomarker
  • glioblastoma
  • macrophages
  • MGMT
  • overall survival
  • prognosis
  • tumor-infiltrating lymphocytes

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