Dodonaea viscosa Jacq: A medicinal plant with cytotoxic effect on colon cancer cell line (HT-29)

Oscar Herrera-Calderon, Md Habibur Rahman, Gilmar Pena-Rojas, Vidalina Andia-Ayme

Research output: Contribution to journalArticlepeer-review

Abstract

Dodonaea viscosa (Family: Sapindaceae) is a medicinal plant that has been used as anti-rheumatic and bone pain in Peru as a folk remedy. ethanol extract obtained from D. viscosa leaves was partitioned as n-hexane fraction; chloroform fraction; ethyl acetate fraction; n-butanol fraction and aqueous fraction. Phytoconstituents from D. viscosa leaves were evaluated by using chemical reagents to identify the presence of each phytochemical. In addition, a cytotoxic effect was determined by the Sulforhodamine B (SRB) test. The results showed that the ethanol extract and ethyl acetate fraction of leaves had the highest variety of phytoconstituents. The ethanol extrac of leaves exhibited a major inhibitory effect compared to different fractions in human colon cancer cells (HT-29). From these assays, it is concluded that D. viscosa does not possess any detectable cytotoxic effect on epidermal cells from mouse (3T3), and a slight cytotoxic effect against HT-29 tumor cells compared to 5-FU. This species could appear like a good source of herbal medicine in colorectal cancer disease.

Original languageEnglish
Pages (from-to)1927-1934
Number of pages8
JournalJournal of Pure and Applied Microbiology
Volume14
Issue number3
DOIs
StatePublished - Sep 2020

Bibliographical note

Publisher Copyright:
© The Author(s) 2020. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

  • Colon cancer
  • Cytotoxic activity
  • Dodonaea viscosa
  • Flavonoids
  • Phytochemicals

Fingerprint

Dive into the research topics of 'Dodonaea viscosa Jacq: A medicinal plant with cytotoxic effect on colon cancer cell line (HT-29)'. Together they form a unique fingerprint.

Cite this