Echinococcus granulosus: Different cytokine profiles are induced by single versus multiple experimental infections in dogs

Andrea Rossi; Juan M. Marqués; Cesar M. Gavidia; Armando E. Gonzalez; Carlos Carmona; Hector H. García; José A. Chabalgoity

doi:10.1016/j.exppara.2011.12.006

Echinococcus granulosus: Different cytokine profiles are induced by single versus multiple experimental infections in dogs

Andrea Rossi, Juan M. Marqués, Cesar M. Gavidia, Armando E. Gonzalez, Carlos Carmona, Hector H. García, José A. Chabalgoity

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Modulation of host responses is an important strategy by which parasites ensure successful establishment and persistence. Host counteraction against this modulation may be required for the host to develop resistance to infection. In this pilot study, experimental infection of dogs with Echinococcus granulosus induced a strong polarization of the cytokine response towards a Th2 phenotype. Consecutive rounds of infection and cure induced resistance to infection resulting in a dramatically lower parasite burden. Repeatedly-infected resistant dogs also lost immune polarization and developed a balanced Th1/Th2 response. No major differences were observed in the production of regulatory cytokines (IL-10, TGF-β) between dogs with high parasite load and dogs with only few intestinal parasites. These results suggest that E. granulosus-driven immunomodulation contributes to successful infection in the definitive host. This information might be relevant for the development of more effective vaccines against this stage of the parasite.

Original language	English
Pages (from-to)	110-115
Number of pages	6
Journal	Experimental Parasitology
Volume	130
Issue number	2
DOIs	https://doi.org/10.1016/j.exppara.2011.12.006
State	Published - Feb 2012

Bibliographical note

Funding Information:
This work was supported by a project grant from C.S.I.C., Uruguay and the NIAID NIH TMRC grant P01 AI51976, Peru, and FIC Training grant TW001140. AR was supported by a fellowship from PEDECIBA, Facultad de Ciencias, Uruguay. HG is now a Wellcome Trust Senior International Research Fellow. We thank Dr. Seth O’Neal for his help in editing this manuscript.

Keywords

Cestodes
Cytokines
Dog
Echinococcus granulosus
Immunomodulation

Access to Document

10.1016/j.exppara.2011.12.006

Cite this

@article{151fad5447f24d5d98d1226ee816e231,

title = "Echinococcus granulosus: Different cytokine profiles are induced by single versus multiple experimental infections in dogs",

abstract = "Modulation of host responses is an important strategy by which parasites ensure successful establishment and persistence. Host counteraction against this modulation may be required for the host to develop resistance to infection. In this pilot study, experimental infection of dogs with Echinococcus granulosus induced a strong polarization of the cytokine response towards a Th2 phenotype. Consecutive rounds of infection and cure induced resistance to infection resulting in a dramatically lower parasite burden. Repeatedly-infected resistant dogs also lost immune polarization and developed a balanced Th1/Th2 response. No major differences were observed in the production of regulatory cytokines (IL-10, TGF-β) between dogs with high parasite load and dogs with only few intestinal parasites. These results suggest that E. granulosus-driven immunomodulation contributes to successful infection in the definitive host. This information might be relevant for the development of more effective vaccines against this stage of the parasite.",

keywords = "Cestodes, Cytokines, Dog, Echinococcus granulosus, Immunomodulation",

author = "Andrea Rossi and Marqu{\'e}s, {Juan M.} and Gavidia, {Cesar M.} and Gonzalez, {Armando E.} and Carlos Carmona and Garc{\'i}a, {Hector H.} and Chabalgoity, {Jos{\'e} A.}",

note = "Funding Information: This work was supported by a project grant from C.S.I.C., Uruguay and the NIAID NIH TMRC grant P01 AI51976, Peru, and FIC Training grant TW001140. AR was supported by a fellowship from PEDECIBA, Facultad de Ciencias, Uruguay. HG is now a Wellcome Trust Senior International Research Fellow. We thank Dr. Seth O{\textquoteright}Neal for his help in editing this manuscript.",

year = "2012",

month = feb,

doi = "10.1016/j.exppara.2011.12.006",

language = "Ingl{\'e}s",

volume = "130",

pages = "110--115",

journal = "Experimental Parasitology",

issn = "0014-4894",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Echinococcus granulosus

T2 - Different cytokine profiles are induced by single versus multiple experimental infections in dogs

AU - Rossi, Andrea

AU - Marqués, Juan M.

AU - Gavidia, Cesar M.

AU - Gonzalez, Armando E.

AU - Carmona, Carlos

AU - García, Hector H.

AU - Chabalgoity, José A.

N1 - Funding Information: This work was supported by a project grant from C.S.I.C., Uruguay and the NIAID NIH TMRC grant P01 AI51976, Peru, and FIC Training grant TW001140. AR was supported by a fellowship from PEDECIBA, Facultad de Ciencias, Uruguay. HG is now a Wellcome Trust Senior International Research Fellow. We thank Dr. Seth O’Neal for his help in editing this manuscript.

PY - 2012/2

Y1 - 2012/2

N2 - Modulation of host responses is an important strategy by which parasites ensure successful establishment and persistence. Host counteraction against this modulation may be required for the host to develop resistance to infection. In this pilot study, experimental infection of dogs with Echinococcus granulosus induced a strong polarization of the cytokine response towards a Th2 phenotype. Consecutive rounds of infection and cure induced resistance to infection resulting in a dramatically lower parasite burden. Repeatedly-infected resistant dogs also lost immune polarization and developed a balanced Th1/Th2 response. No major differences were observed in the production of regulatory cytokines (IL-10, TGF-β) between dogs with high parasite load and dogs with only few intestinal parasites. These results suggest that E. granulosus-driven immunomodulation contributes to successful infection in the definitive host. This information might be relevant for the development of more effective vaccines against this stage of the parasite.

AB - Modulation of host responses is an important strategy by which parasites ensure successful establishment and persistence. Host counteraction against this modulation may be required for the host to develop resistance to infection. In this pilot study, experimental infection of dogs with Echinococcus granulosus induced a strong polarization of the cytokine response towards a Th2 phenotype. Consecutive rounds of infection and cure induced resistance to infection resulting in a dramatically lower parasite burden. Repeatedly-infected resistant dogs also lost immune polarization and developed a balanced Th1/Th2 response. No major differences were observed in the production of regulatory cytokines (IL-10, TGF-β) between dogs with high parasite load and dogs with only few intestinal parasites. These results suggest that E. granulosus-driven immunomodulation contributes to successful infection in the definitive host. This information might be relevant for the development of more effective vaccines against this stage of the parasite.

KW - Cestodes

KW - Cytokines

KW - Dog

KW - Echinococcus granulosus

KW - Immunomodulation

UR - http://www.scopus.com/inward/record.url?scp=84856032180&partnerID=8YFLogxK

U2 - 10.1016/j.exppara.2011.12.006

DO - 10.1016/j.exppara.2011.12.006

M3 - Artículo

C2 - 22202182

AN - SCOPUS:84856032180

SN - 0014-4894

VL - 130

SP - 110

EP - 115

JO - Experimental Parasitology

JF - Experimental Parasitology

IS - 2

ER -

Echinococcus granulosus: Different cytokine profiles are induced by single versus multiple experimental infections in dogs

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this