Efecto gastroprotector y antisecretor de un fitofármaco de hojas de matico (Piper aduncum)

Translated title of the contribution: Gastroprotective and antisecretory effect of a phytochemical made from matico leaves (Piper aduncum)

Jorge Luis Arroyo Acevedo, Pablo Enrique Bonilla Rivera, Luis Moreno-Exebio, Sergio Gerardo Ronceros Medrano, Gloria Tomás, Juana Huamán, Ernesto Raez, Mariano Quino, Javier Rodriguez-Calzado

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives. To determine the gastroprotective and antisecretory effect of ethanol extract from matico leaves (Piper aduncum) in animal models. Materials and methods. To evaluate the gastroprotective effect, 220 mice of the Balb C57 strain were used. They were randomized in 22 groups of ten animals each, in which the formation of gastric ulcers was induced with indomethacin. Gastroprotection was determined by evaluating three aspects: inflammation, number of hemorrhagic shocks and number of ulcers. To evaluate the antisecretory effect, 64 white male Holtzman rats were used, which were randomized in eight groups of eight animals, one control and seven groups of treatment with one extract dose level and two phytochemical dose levels. Antisecretion was obtained through the pylorus ligation. Results. Regarding gastroprotection, dichloromethane, chloroform, hexane and methanol extracts decreased inflammation to over 66% (p<0,05). The ethanolic extract shows 100% activity in reducing the number of hemorrhagic bands (p<0,05). The chloroform extract shows antiulcer activity at 75% (p<0,05). In terms of antisecretion, the phytochemical in capsules containing the ethanolic extract achieved 72% reduction of the gastric secretion volume (p<0,01) and 104,3% (p<0,01) PH increase. Conclusions. In experimental conditions, ethanolic extracts, their fractions and phytochemicals have a gastroprotective effect in mice and antisecretory effect in rats.

Translated title of the contributionGastroprotective and antisecretory effect of a phytochemical made from matico leaves (Piper aduncum)
Original languageSpanish
Pages (from-to)608-615
Number of pages8
JournalRevista Peruana de Medicina de Experimental y Salud Publica
Issue number4
StatePublished - 2013
Externally publishedYes


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