Effect of intravenous infusion of KCL on the electrocardiogram and serum potassium in dogs with normal renal function

Jessica Bravo-Zúñiga, Julio Huapaya, Cesar Valencia, Sandra Bezada, Cristian Leon, Renato Ferrandiz-Espadin, Javier Cieza

Research output: Contribution to journalArticle

Abstract

© 2015, Instituto Nacional de Salud. All rights reserved. Variations in serum potassium (K+) and electrocardiographic changes at different infusion speeds of intravenous K+ were studied in dogs. Solutions of 20, 40, 60 and 80 mEq of K+ were infused in one hour to dogs with normal renal function and normal serum K+. Nine dogs were studied: three without prior hydration and six with previous hydration. Infusing 20 mEq / hour of K+ produced an increase in heart rate without changes in the electrocardiogram. With 40 mEq / hour there were changes in the “t” and “p” waves, and with 60 and 80 mEq / hour, alterations consistent with cardiac ischemia and ventricular tachycardia. Dogs without hydration had more obvious and fatal electrocardiographic changes. Doses of 20 mEq / hour of K + caused no morbidity or mortality in the animals studied. Higher doses showed various complications which depended on the hydration status of the animal, its urinary flow and potassium level.
Original languageAmerican English
Pages (from-to)110-116
Number of pages7
JournalRevista Peruana de Medicina Experimental y Salud Publica
StatePublished - 1 Jan 2015
Externally publishedYes

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