Efecto de lepidium meyenii (maca) sobre la producción de tres citoquinas hematopoyéticas en esplenocitos de ratones inmunosuprimidos

Translated title of the contribution: Effect of Lepidium meyenii (maca) on the production of three hematopoietic cytokines in splenocytes from immunosuppressed mice

Evelyn Alvarez, Libertad Alzamora-Gonzales

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Lepidium meyenii Walp, Brassicaceae (Maca) is a plant native to Peru to conferring immunostimulatory activity. The objective was to evaluate the immunomodulatory effect of the aqueous extract (EAc) of yellow ecotype on gene expression of three hematopoietic cytokines (IL-3, GM-CSF and IL-7) in splenocytes from Balb/c mice immunosuppressed with cyclophosphamide. Levels of mRNA were measured by RT-PCR. Two days after immunosuppression (IS), in splenocytes from mice treated with EAc increased expression of mRNA was demonstrated for IL-3, GM-CSF e IL-7 (p < 0.05) compared to the untreated group. Five days after IS, in mice treated with EAc found higher cell counts in bone marrow, peripheral blood and endogenous colonies formed units in spleen compared to the untreated group. It is concluded that administration of EAc in immunocompromised mice can reverse the suppressive effects of cyclophosphamide.

Translated title of the contributionEffect of Lepidium meyenii (maca) on the production of three hematopoietic cytokines in splenocytes from immunosuppressed mice
Original languageSpanish
Pages (from-to)313-321
Number of pages9
JournalBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Volume12
Issue number3
StatePublished - 2013
Externally publishedYes

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