Efficacy and effectiveness of mefloquine and artesunate combination therapy for uncomplicated Plasmodium falciparum malaria in the Peruvian Amazon

Alexandre Macedo De Oliveira, Jorge Chavez, Gabriel Ponce De Leon, Salomon Durand, Nancy Arrospide Velasco, Jacquelin Roberts, Cesar Augusto Cabezas Sanchez, Wilmer Marquino

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We evaluated the efficacy and effectiveness of mefloquine (MQ) plus artesunate (AS) to treat patients with uncomplicated malaria in the Peruvian Amazon Basin in April 2005.March 2006. Patients ≥1 year of age with fever (axillary temperature ≥ 37.5°C) or history of fever and Plasmodium falciparum monoinfection were included. Patients received antimalarial treatment with MQ (12.5 mg/kg/day for two days) and AS (4.0 mg/kg/day for three days) either by directly observed therapy or without directly observed therapy. After a 28-day follow-up, treatment efficacy and effectiveness were assessed on the basis of clinical and parasitologic outcomes. Ninety-six patients were enrolled in each study group; nine patients were lost to follow-up. All patients, except for one in the observed group, demonstrated adequate clinical and parasitologic response; none had detectable parasitemia on day 3. The efficacy of MQ + AS efficacy was 98.9% (95% confidence interval = 94.1.100.0%) and the effectiveness was 100.0% (95% confidence interval = 95.9.100.0%). Our study shows that MQ + AS is highly efficacious in the Peruvian Amazon.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume85
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

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