Eficacia de dos formulaciones de oxfendazol producidas localmente para el tratamiento de la cisticercosis en cerdos infectados naturalmente

Translated title of the contribution: Efficacy of two locally produced oxfendazole formulations for the treatment of cysticercosis in naturally infected pigs

Grupo de Trabajo en Cisticercosis en Perú.

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of two locally produced oxfendazole (OFZ) formulations against cysticercosis at 22,5% and 10%, versus a commercial formulation (Synanthic 9,06%) was evaluated in twenty-two naturally infected pigs that received a single oral dose of 30 mg/kg. Pigs were sacrificed at eight weeks post-treatment to evaluate the cysts found in their carcasses, and to determine the cysticidal efficacy, which was defined as the proportion of degenerated cysts over total cysts. Only degenerated cysts were found in muscle, heart, and tongue of pigs treated with OFZ in all groups, which shows an efficacy of 100%. Viable and degenerated cysts were found in brains, being the efficacy lower in all groups (65% [commercial OFZ], 47% [local OFZ 22.5%] and 31% [local OFZ 10%], p = 0.355). Locally produced OFZ formulations were similarly effective to the commercial formulation and may provide a practical alternative for the treatment of porcine cysticercosis.

Translated title of the contributionEfficacy of two locally produced oxfendazole formulations for the treatment of cysticercosis in naturally infected pigs
Original languageSpanish
Pages (from-to)296-301
Number of pages6
JournalRevista Peruana de Medicina de Experimental y Salud Publica
Volume38
Issue number2
DOIs
StatePublished - 1 Apr 2021
Externally publishedYes

Bibliographical note

Funding Information:
Este estudio fue financiado por el Centro Internacional Fogarty/NIH (becas de capacitaci?n n?meros D43TW008273-05 y D43TW001140).

Publisher Copyright:
© 2021, Instituto Nacional de Salud. All rights reserved.

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