The efficacy of two locally produced oxfendazole (OFZ) formulations against cysticercosis at 22,5% and 10%, versus a commercial formulation (Synanthic 9,06%) was evaluated in twenty-two naturally infected pigs that received a single oral dose of 30 mg/kg. Pigs were sacrificed at eight weeks post-treatment to evaluate the cysts found in their carcasses, and to determine the cysticidal efficacy, which was defined as the proportion of degenerated cysts over total cysts. Only degenerated cysts were found in muscle, heart, and tongue of pigs treated with OFZ in all groups, which shows an efficacy of 100%. Viable and degenerated cysts were found in brains, being the efficacy lower in all groups (65% [commercial OFZ], 47% [local OFZ 22.5%] and 31% [local OFZ 10%], p = 0.355). Locally produced OFZ formulations were similarly effective to the commercial formulation and may provide a practical alternative for the treatment of porcine cysticercosis.
|Translated title of the contribution||Efficacy of two locally produced oxfendazole formulations for the treatment of cysticercosis in naturally infected pigs|
|Number of pages||6|
|Journal||Revista Peruana de Medicina Experimental y Salud Publica|
|State||Published - 1 Apr 2021|
Bibliographical noteFunding Information:
Este estudio fue financiado por el Centro Internacional Fogarty/NIH (becas de capacitación números D43TW008273-05 y D43TW001140).
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