Epidemiology of Andean cutaneous leishmaniasis: Incrimination of Lutzomyia ayacuchensis (Diptera: Psychodidae) as a vector of Leishmania in geographically isolated, upland valleys of Peru

Abraham German Caceres Lazaro, Pablo Villaseca, Jean Claude Dujardin, Anne Laure Bañuls, Rocio Inga, Martin Lopez, Margarita Arana, Dominique Le Ray, Jorge Arevalo

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The southernmost limit of the distribution of endemic Andean cutaneous leishmaniasis (CL), commonly known as Uta, is localized in the western Andean valleys of Ayacucho, Peru. This area is completely isolated from other regions endemic for this disease. Identification of the insect vector for Andean CL was carried out by combining entomologic and parasitologic approaches. Two Lutzomyia species were captured: Lutzomyia ayacuchensis and Lu. noguchii. The former species was considered responsible for transmission of Leishmania because 1) there was a coincidence in space and time between the presence of this insect and the distribution of Andean CL, 2) it was shown to be highly anthropophilic, 3) Leishmania parasites of the subgenus Viannia were detected by a specific polymerase chain reaction assay, 4) promastigotes isolated from this insect were shown by multilocus enzyme electrophoresis and molecular karyotyping to belong to the same deme of Leishmania (Viannia) peruviana as the one circulating in humans living in the study area, and 5) the complete cycle of L. (V.) peruviana was observed in experimental infections of Lu. ayacuchensis. Parasite and vector homogeneity found in Ayacucho contrasted with the heterogeneity reported for other areas endemic for Andean CL. The potential influence of ecologic determinants on this geographically isolated area is discussed.

Original languageEnglish
Pages (from-to)607-612
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume70
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint Dive into the research topics of 'Epidemiology of Andean cutaneous leishmaniasis: Incrimination of Lutzomyia ayacuchensis (Diptera: Psychodidae) as a vector of Leishmania in geographically isolated, upland valleys of Peru'. Together they form a unique fingerprint.

Cite this