Epidemiology of invasive Streptococcus pneumoniae infections in children in Spain, 1996-1998

J. Díez-Domingo, I. Pereiró, A. Morant, C. Gimeno, M. Lerma, I. Oyagüez, A. González, A. Gómez, M. D. Rabasco, R. Moreno, A. Rosales, R. Escoms, J. Haro, A. Lloret, J. M. García, A. Martínez, A. Hernández, A. Viudes, M. A. Balaguer, V. DomínguezN. De la Muela, R. Llucián, J. M. Nogueira, J. J. Camarena, A. Sńchez, M. J. Jiménez, R. Igual, J. Marín, D. Grande, R. Ferreruela, A. Hervás, C. Serrat, J. M. Paricio, C. Martinez, P. Perez, P. López, A. Herrero, F. Buñuel, F. Alexandre, V. Ortíz de la Tabla, R. González, C. Blesa, C. Tabernero, E. Navarro, T. Perez, G. Royo, M. Aceituno, A. Yagüe, F. Goberna

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27 Scopus citations


Background: Streptococcus pneumoniae is a significant cause of meningitis and septicemia in early infancy, being associated to a high case-fatality rates and serious sequelae. Objective: To investigate the burden of invasive disease caused by S. pneumoniae in Valencia, Spain, during a three-year period (1996-1998). Methods: Hospital-based prospective active surveillance program for invasive bacterial diseases in children ≤ 15 years of age in Valencia, from December 1, 1995 to January 1999. Results: A total of 94 cases of invasive pneumococcal disease were detected in patients ≤ 15 years of age. The overall annual incidence of invasive pneumococcal disease was 4.6/100,000 persons, ≤ 15 years of age. The incidence of invasive disease and meningitis was higher among children younger than 2 years of age (16.8 and 3.8, respectively). Serotypes 19, 14 and 6 accounted for 83% of the isolates. Conclusions: The age distribution of invasive pneumococcal disease and meningitis shows a peak in the first two years of life and a decline thereafter. Serotypes 19, 14 and 6 are those primarily responsible for invasive pneumococcal disease in children of this region of Spain.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalJournal of Infection
Issue number3
StatePublished - Oct 2002

Bibliographical note

Funding Information:
This study was supported by the Dirección Área 4, Generalitat Valenciana, IVESP (Ref. 96/021), Fondo de Investigaciones Sanitarias (Ref.97/0842) and Aventis Pasteur MSD, Spain.


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