Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru

Brett M. Forshey; Allison Stewart; Amy C. Morrison; Hugo Gálvez; Claudio Rocha; Helvio Astete; Dominique Eza; Hua Wei Chen; Chien Chung Chao; Joel M. Montgomery; David E. Bentzel; Wei Mei Ching; Tadeusz J. Kochel

doi:10.4269/ajtmh.2010.09-0355

Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru

Brett M. Forshey, Allison Stewart, Amy C. Morrison, Hugo Gálvez, Claudio Rocha, Helvio Astete, Dominique Eza, Hua Wei Chen, Chien Chung Chao, Joel M. Montgomery, David E. Bentzel, Wei Mei Ching, Tadeusz J. Kochel

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Abstract

A seroprevalence study for IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) Rickettsia among humans and domestic pets was conducted in the city of Iquitos, located in the Amazon basin of Peru. Of 1,195 human sera analyzed, 521 (43.6%) and 123 (10.3%) were positive for SFGR and TGR antibodies, respectively. District of residence and participant age were associated with antibody positivity for both groups, whereas rodent sightings in the home were associated with TGR antibody positivity. Of the 71 canines tested, 42 (59.2%) were positive for SFGR antibodies, and two (2.8%) were positive for TGR antibodies; one active SFGR infection was detected by polymerase chain reaction. An uncharacterized SFGR species was detected in 95.9% (71/74) of Ctenocephalides felis pools collected from domestic pets. These data suggest that rickettsial transmission is widespread in Iquitos. Rickettsia species should be further explored as potential causes of acute febrile illnesses in the region. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.

Original language	American English
Pages (from-to)	683-690
Number of pages	8
Journal	American Journal of Tropical Medicine and Hygiene
DOIs	https://doi.org/10.4269/ajtmh.2010.09-0355
State	Published - 1 Apr 2010

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Forshey, B. M., Stewart, A., Morrison, A. C., Gálvez, H., Rocha, C., Astete, H., Eza, D., Chen, H. W., Chao, C. C., Montgomery, J. M., Bentzel, D. E., Ching, W. M., & Kochel, T. J. (2010). Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru. American Journal of Tropical Medicine and Hygiene, 683-690. https://doi.org/10.4269/ajtmh.2010.09-0355

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title = "Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru",

abstract = "A seroprevalence study for IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) Rickettsia among humans and domestic pets was conducted in the city of Iquitos, located in the Amazon basin of Peru. Of 1,195 human sera analyzed, 521 (43.6%) and 123 (10.3%) were positive for SFGR and TGR antibodies, respectively. District of residence and participant age were associated with antibody positivity for both groups, whereas rodent sightings in the home were associated with TGR antibody positivity. Of the 71 canines tested, 42 (59.2%) were positive for SFGR antibodies, and two (2.8%) were positive for TGR antibodies; one active SFGR infection was detected by polymerase chain reaction. An uncharacterized SFGR species was detected in 95.9% (71/74) of Ctenocephalides felis pools collected from domestic pets. These data suggest that rickettsial transmission is widespread in Iquitos. Rickettsia species should be further explored as potential causes of acute febrile illnesses in the region. Copyright {\textcopyright} 2010 by The American Society of Tropical Medicine and Hygiene.",

author = "Forshey, {Brett M.} and Allison Stewart and Morrison, {Amy C.} and Hugo G{\'a}lvez and Claudio Rocha and Helvio Astete and Dominique Eza and Chen, {Hua Wei} and Chao, {Chien Chung} and Montgomery, {Joel M.} and Bentzel, {David E.} and Ching, {Wei Mei} and Kochel, {Tadeusz J.}",

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doi = "10.4269/ajtmh.2010.09-0355",

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Forshey, BM, Stewart, A, Morrison, AC, Gálvez, H, Rocha, C, Astete, H, Eza, D, Chen, HW, Chao, CC, Montgomery, JM, Bentzel, DE, Ching, WM & Kochel, TJ 2010, 'Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru', American Journal of Tropical Medicine and Hygiene, pp. 683-690. https://doi.org/10.4269/ajtmh.2010.09-0355

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T1 - Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru

AU - Forshey, Brett M.

AU - Stewart, Allison

AU - Morrison, Amy C.

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AU - Rocha, Claudio

AU - Astete, Helvio

AU - Eza, Dominique

AU - Chen, Hua Wei

AU - Chao, Chien Chung

AU - Montgomery, Joel M.

AU - Bentzel, David E.

AU - Ching, Wei Mei

AU - Kochel, Tadeusz J.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - A seroprevalence study for IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) Rickettsia among humans and domestic pets was conducted in the city of Iquitos, located in the Amazon basin of Peru. Of 1,195 human sera analyzed, 521 (43.6%) and 123 (10.3%) were positive for SFGR and TGR antibodies, respectively. District of residence and participant age were associated with antibody positivity for both groups, whereas rodent sightings in the home were associated with TGR antibody positivity. Of the 71 canines tested, 42 (59.2%) were positive for SFGR antibodies, and two (2.8%) were positive for TGR antibodies; one active SFGR infection was detected by polymerase chain reaction. An uncharacterized SFGR species was detected in 95.9% (71/74) of Ctenocephalides felis pools collected from domestic pets. These data suggest that rickettsial transmission is widespread in Iquitos. Rickettsia species should be further explored as potential causes of acute febrile illnesses in the region. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.

AB - A seroprevalence study for IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) Rickettsia among humans and domestic pets was conducted in the city of Iquitos, located in the Amazon basin of Peru. Of 1,195 human sera analyzed, 521 (43.6%) and 123 (10.3%) were positive for SFGR and TGR antibodies, respectively. District of residence and participant age were associated with antibody positivity for both groups, whereas rodent sightings in the home were associated with TGR antibody positivity. Of the 71 canines tested, 42 (59.2%) were positive for SFGR antibodies, and two (2.8%) were positive for TGR antibodies; one active SFGR infection was detected by polymerase chain reaction. An uncharacterized SFGR species was detected in 95.9% (71/74) of Ctenocephalides felis pools collected from domestic pets. These data suggest that rickettsial transmission is widespread in Iquitos. Rickettsia species should be further explored as potential causes of acute febrile illnesses in the region. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.

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ER -

Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru

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