TY - JOUR
T1 - Evaluación preclínica y clínica de la actividad hipoglucemiante de Inca sayre (Argyrochosma nivea (Poir.) Windham) en diabetes mellitus tipo 2
AU - Moscoso Mujica, Gladys Angelica
AU - Mujica, Ángel
AU - Vegas, Carlos
AU - Villena, Magaly
AU - Alvizuri, Humberto
N1 - Publisher Copyright:
© 2017, CITA Publicaciones y Documentacion. All rights reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Inca sayre (Argyrochosma nivea (Poir.) Windham, synonim: Notholaena nivea (Poiret) Desv.) is a Pteridaceae of the Andean region of Peru used in Incan traditional medicine. The aim of this study was to perform the preclinical and clinical evaluation of the hypoglycemic activity of Inca sayre extract in type 2 diabetes mellitus. For this, preclinical evaluation of acute toxicity in mice, and hypoglycemic activity in normoglycemic rats and with experimentally induced diabetes was performed. Clinical evaluation was done in normoglycemic volunteers and type 2 diabetic patients. The results showed hypoglycemic activity of the extract in both preclinical and clinical evaluations. The blood sugar levels in normoglycemic volunteers decreased 11% in comparison to the baseline (p ≤ 0.05). In type 2 diabetic patients reduced 9.0%, 8.2% and 6.2% on the third, fifth and seventh day, respectively, in relation to oral antidiabetics (p ≤ 0.05), and 21.2%, 20.4% and 18.6%, respectively, in relation to placebo (p ≤ 0.05). In addition, the extract produced greater metabolic control of glycaemia in glucose tolerance test (PTOGA).
AB - Inca sayre (Argyrochosma nivea (Poir.) Windham, synonim: Notholaena nivea (Poiret) Desv.) is a Pteridaceae of the Andean region of Peru used in Incan traditional medicine. The aim of this study was to perform the preclinical and clinical evaluation of the hypoglycemic activity of Inca sayre extract in type 2 diabetes mellitus. For this, preclinical evaluation of acute toxicity in mice, and hypoglycemic activity in normoglycemic rats and with experimentally induced diabetes was performed. Clinical evaluation was done in normoglycemic volunteers and type 2 diabetic patients. The results showed hypoglycemic activity of the extract in both preclinical and clinical evaluations. The blood sugar levels in normoglycemic volunteers decreased 11% in comparison to the baseline (p ≤ 0.05). In type 2 diabetic patients reduced 9.0%, 8.2% and 6.2% on the third, fifth and seventh day, respectively, in relation to oral antidiabetics (p ≤ 0.05), and 21.2%, 20.4% and 18.6%, respectively, in relation to placebo (p ≤ 0.05). In addition, the extract produced greater metabolic control of glycaemia in glucose tolerance test (PTOGA).
KW - Argyrochosma nivea
KW - Hypoglycaemic activity
KW - Notholaena nivea
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85049261689&partnerID=8YFLogxK
M3 - Artículo
AN - SCOPUS:85049261689
SN - 1576-0952
VL - 17
SP - 165
EP - 174
JO - Revista de Fitoterapia
JF - Revista de Fitoterapia
IS - 2
ER -