Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.
Mayta, H., Gilman, R. H., Arenas, F., Valencia, T., Caviedes, L., Montenegro, S. H., Ticona, E., Ortiz, J., Chumpitaz, R., Evans, C. A., & Williams, D. L. (2003). Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru. Journal of Clinical Microbiology, 5774-5777. https://doi.org/10.1128/JCM.41.12.5774-5777.2003