Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

Ana Vargas-Calla, Luis A. Gomez-Puerta, Juan Calcina, Omar Gonzales-Viera, Cesar Gavidia, Maria T. Lopez-Urbina, Hector H. Garcia, Armando E. Gonzalez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objective: To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis. Methods: Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight, the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo (control group). All animals were kept under the same management conditions. The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups. Results: All pigs treated with oxfendazole had only degenerated cysts in their carcasses. In contrast, TCBZ had very little effect against the parasitic cysts. Cysts from pigs in the TCBZ group looked apparently normal after treatment. However, histological evaluation showed a mild to moderate degree of inflammation. Conclusions: TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalAsian Pacific Journal of Tropical Medicine
Volume9
Issue number1
DOIs
StatePublished - 1 Jan 2016

Bibliographical note

Funding Information:
Partial support from the Fogarty International Center/NIH (training grants D43 TW008273-03 and D43 TW001140 ) is acknowledged. Luis A. Gomez-Puerta's PhD study, Ana Vargas Calla's MSc study, and Juan Calcina's MSc study are supported by the Fogarty International Center/NIH (D43 TW008273-03>). Hector H. Garcia is supported by a Wellcome Trust Senior International Research Fellowship in Public Health and Tropical Medicine. Many thanks are also due to Dr. Narry Tiao for the comments and critique of the manuscript.

Publisher Copyright:
© 2016 Hainan Medical College.

Keywords

  • Cysticercosis
  • Oxfendazole
  • Taenia solium
  • Treatment
  • Triclabendazole

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