Evaluation of immunodiagnostics for toxocarosis in experimental porcine cysticercosis

Hector H. García, Gabriella Cancrini, Filippo Bartalesi, Silvia Rodriguez, Juan A. Jimenez, William Roldan, Antonia Mantella, Alessandra Nicoletti, Alessandro Bartoloni

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We assessed whether immunodiagnostic tests for cysticercosis can cross-react with the currently available immunodiagnostic tests for Toxocara canis in an established animal model for cysticercosis infection in pigs, known host for Toxocara. We examined by TES-enzyme-linked immunosorbent test and immunoblot assay for toxocarosis and cysticercosis the baseline and final follow-up sera of 10 pigs, before and after (3 months) infection with Taenia solium. After successful cysticercosis infection, the nine evaluable pigs became seropositive to T. solium (enzyme-linked immunoelectrotransfer blot assay), but did remain seronegative for Toxocara in both assays, documenting the lack of cross-reactivity with anti-T. solium antibodies in both T. canis assays. These findings should help clinicians better interpret serology for toxocariosis and cysticercosis in endemic areas for both helminth infections.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalTropical Medicine and International Health
Volume12
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Cysticercosis
  • Epilepsy
  • Immunodiagnosis
  • Pig
  • Toxocarosis

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